A comprehensive review on wedelolactone: natural sources, total syn-thesis, and pharmacological activities

被引：1

作者：

Cai, Haiping

Wu, Yue

Zhang, Xiaojin ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 211198, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2025年 / 23卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Natural product; Wedelolactone; Pharmacological activity; Synthesis; Mechanism; BREAST-CANCER CELLS; NF-KAPPA-B; ECLIPTA-ALBA; WEDELIA-CALENDULACEA; OXIDATIVE STRESS; IN-VITRO; ENHANCES OSTEOBLASTOGENESIS; ASSISTED EXTRACTION; SIGNALING PATHWAY; LIVER-INJURY;

D O I：

10.1016/S1875-5364(25)60821-1

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Plant-derived natural products have long been a vital source for developing therapeutic drugs. Wedelolactone (WDL), a coumestan isolated from Eclipta prostrata, Wedelia calendulacea, Wedelia chinensis, and Sphagneticola trilobata, demonstrates a broad spectrum of therapeutic potential, including anticancer, anti-inflammatory, anti-obesity, anti-myotoxic, antimicrobial, anti-diabetic, and tissue-protective activities. This review synthesizes information on the isolation, total synthesis, pharmacological activity, underlying mechanisms, and pharmacokinetic properties of WDL. Additionally, it offers insights into potential clinical applications and future drug discovery avenues utilizing WDL or its derivatives, either independently or in combination with other pharmaceuticals.

引用

页码：169 / 181

页数：13

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