Exploring the contribution of genetics on the clinical manifestations of systemic lupus erythematosus

被引：4

作者：

Rodriguez, Ruth D. ^{[1
]}

Alarcon-Riquelme, Marta E. ^{[1
,2
]}

机构：

[1] Univ Granada, Pfizer, Andalusian Govt, Ctr Genom & Oncol Res GENyO, Granada, Spain

[2] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2024年 / 38卷 / 04期

基金：

瑞典研究理事会;

关键词：

Systemic lupus erythematosus; Genetics; Neuropsychiatric lupus; Lupus nephritis; Cutaneous lupus; GENOME-WIDE ASSOCIATION; STAGE RENAL-DISEASE; SUSCEPTIBILITY LOCI; INCREASED RISK; T-CELLS; NEPHRITIS; ITGAM; EXPRESSION; VARIANTS; TREX1;

D O I：

10.1016/j.berh.2024.101971

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by diverse clinical manifestations affecting multiple organs and systems. The understanding of genetic factors underlying the various manifestations of SLE has evolved considerably in recent years. This review provides an overview of the genetic implications in some of the most prevalent manifestations of SLE, including renal involvement, neuropsychiatric, cutaneous, constitutional, musculoskeletal, and cardiovascular manifestations. We discuss the current state of knowledge regarding the genetic basis of these manifestations, highlighting key genetic variants and pathways implicated in their pathogenesis. Additionally, we explore the clinical implications of genetic findings, including their potential role in risk stratification, prognosis, and personalized treatment approaches for patients with SLE. Through a comprehensive examination of the genetic landscape of SLE manifestations, this review aims to provide insights into the underlying mechanisms driving disease heterogeneity and inform future research directions in this field.

引用

页数：10

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