Targeting AMP-activated protein kinase in sepsis

被引：0
作者：
Yumoto, Tetsuya [1 ,2 ,3 ]
Coopersmith, Craig M. [1 ,2 ]
机构：
[1] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30307 USA
[2] Emory Univ, Emory Crit Care Ctr, Sch Med, Atlanta, GA 30307 USA
[3] Okayama Univ, Fac Med, Dept Emergency Crit Care & Disaster Med, Okayama, Japan
来源：
FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷
基金：
美国国家卫生研究院;
关键词：
AMP activated kinase; metformin; AICAR; sepsis; treatment; MACROPHAGE POLARIZATION; HMGB1; RELEASE; ORGAN INJURY; LIVER-INJURY; METFORMIN; PATHWAY; AUTOPHAGY; SURVIVAL; INFLAMMATION; ENDOTOXEMIA;
D O I：
10.3389/fendo.2024.1452993
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sepsis is a global health challenge marked by limited clinical options and high mortality rates. AMP-activated protein kinase (AMPK) is a cellular energy sensor that mediates multiple crucial metabolic pathways that may be an attractive therapeutic target in sepsis. Pre-clinical experimental studies have demonstrated that pharmacological activation of AMPK can offer multiple potential benefits during sepsis, including anti-inflammatory effects, induction of autophagy, promotion of mitochondrial biogenesis, enhanced phagocytosis, antimicrobial properties, and regulation of tight junction assembly. This review aims to discuss the existing evidence supporting the therapeutic potential of AMPK activation in sepsis management.
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页数：11
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