Hypersensitivity reactions after diagnostic nonvascular administration of iodine-based contrast media and gadolinium-based contrast agents and the role of the drug allergy specialist

被引：1
作者：
van der Molen, Aart J. [1 ]
Vega, Francisco [2 ]
van de Ven, Annick A. J. M. [3 ]
Dekkers, Ilona A. [1 ]
Laguna, Jose J. [4 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Radiol, C-2S,Albinusdreef 2, NL-2333 Leiden, ZA, Netherlands
[2] Hosp Univ Princesa, Dept Allergy, Madrid, Spain
[3] Univ Med Ctr Groningen, Dept Internal Med, Div Allergol, Groningen, Netherlands
[4] Hosp Univ Cruz Roja, Allergy Unit, Allergo Anaesthesia Unit, Madrid, Spain
来源：
EUROPEAN JOURNAL OF RADIOLOGY | 2024年 / 181卷
关键词：
Contrast media/administration and dosage; Drug administration routes; Hypersensitivity; Fluoroscopy; Tomography; X-ray computed; Magnetic resonance imaging; IMMEDIATE HYPERSENSITIVITY; ADVERSE-REACTIONS; LOW-OSMOLAR; ANAPHYLACTOID REACTION; RADIOCONTRAST MEDIA; COMPUTED-TOMOGRAPHY; RENAL EXCRETION; SKIN-TESTS; CORTICOSTEROID PROPHYLAXIS; GADOPENTETATE DIMEGLUMINE;
D O I：
10.1016/j.ejrad.2024.111803
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The risk of hypersensitivity reactions (HSR) following nonvascular administration of contrast media (CM) for diagnostic studies is very low, likely due to minimal absorption into the systemic circulation. Most published individual cases of HSR after nonvascular CM administration are immediate reactions caused by ionic highosmolar CM, few by nonionic low-osmolar CM, and none by gadolinium-based contrast agents. Measures to prevent recurrent HSR following nonvascular administration are similar to those recommended to prevent HSR after intravascular CM administration. Premedication as preventive measure has been abandoned, while switching to an alternative CM, preferably based on the results of an allergological analysis, is increasingly advocated. In selected scenarios, preventive measures may be minimized.
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页数：10
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