The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations - A narrative review

被引:6
作者
Huang, Kai [1 ]
Cai, Haili [2 ]
机构
[1] Tongde Hosp Zhejiang Prov, Hangzhou 310012, Peoples R China
[2] Peoples Liberat Army, Hosp 903, Hangzhou 310013, Peoples R China
基金
中国国家自然科学基金;
关键词
Osteoarthritis; Osteoporosis; Pathophysiological mechanisms; FOXO TRANSCRIPTION FACTORS; BONE-MINERAL DENSITY; ARTICULAR-CARTILAGE; OSTEOPONTIN; ASSOCIATION; PATHOGENESIS; POLYMORPHISM; PROGRESSION; SEVERITY; MEDIATOR;
D O I
10.1016/j.exger.2024.112614
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
This comprehensive review examines the relationship between osteoarthritis (OA) and osteoporosis (OP), two common disorders in the elderly. OA involves joint cartilage degeneration and pain, while OP leads to fractures due to reduced bone mass. Despite different pathologies, both conditions share risk factors such as age and genetics. Studies reveal mixed results: some show higher bone mineral density (BMD) in OA patients, suggesting an inverse relationship, while others find no significant link. Proposed mechanisms include mechanical loading, bone remodeling, and inflammation. Clinical strategies focus on maintaining bone health in OA and monitoring joint health in OP, with treatments like bisphosphonates and exercise. Understanding these interactions is crucial for developing integrated treatments to improve patient outcomes and quality of life. Further research is needed to clarify these complex mechanisms.
引用
收藏
页数:7
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