Cerebellar abscess caused by Cladophialophora bantiana involving an elderly Japanese woman

被引：0

作者：

Nakamoto, Kenta ^{[1
,2
]}

Hagiya, Hideharu ^{[1
]}

Fukushima, Shinnosuke ^{[1
,3
]}

Oguni, Kohei ^{[1
,2
]}

Yokoyama, Yukika ^{[4
]}

Iio, Koji ^{[4
]}

Hirano, Shuichiro ^{[5
]}

Yaguchi, Takashi ^{[6
]}

Ban, Sayaka ^{[6
]}

Watanabe, Akira ^{[6
]}

Okunobu, Hiroki ^{[2
]}

Suyama, Atsuhito ^{[2
]}

Kawaguchi, Marina ^{[2
]}

Sazumi, Yousuke ^{[2
]}

Otsuka, Fumio ^{[2
]}

机构：

[1] Okayama Univ Hosp, Dept Infect Dis, 2-5-1 Shikata Cho,Kita Ku, Okayama 7008558, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Med, Okayama, Japan

[3] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Bacteriol, Okayama, Japan

[4] Okayama Univ Hosp, Microbiol Div, Clin Lab, Okayama, Japan

[5] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol Surg, Okayama, Japan

[6] Chiba Univ, Med Mycol Res Ctr, Div Clin Res, Chiba, Japan

来源：

JOURNAL DE MYCOLOGIE MEDICALE | 2025年 / 35卷 / 02期

关键词：

Brain abscess; Cladophialophora bantiana; Black fungus; Phaeohyphomycosis; Posaconazole; BRAIN-ABSCESS; CEREBRAL PHEOHYPHOMYCOSIS; FUNGAL-INFECTIONS; POSACONAZOLE; THERAPY;

D O I：

10.1016/j.mycmed.2025.101548

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phaeohyphomycosis is a rare fungal infection that presents significant challenges in diagnosis and treatment. Herein, we document a case of a cerebellar abscess caused by Cladophialophora bantiana. A 77-year-old woman with type 2 diabetes mellitus and a previous history of diffuse large B-cell lymphoma gradually developed ataxia and was transferred to an emergency department. Head imaging investigations indicated a cerebellar mass and the patient underwent an emergent endoscopic drainage. Although bacterial cultures of the drainage specimen yielded no growth, a dematiaceous fungus was isolated and subsequently identified as C. bantiana through ITS sequencing analysis. The patient received antifungal combination therapy, initially with liposomal amphotericin B and voriconazole, and finally posaconazole and 5-fluorocytosine. Brain abscesses caused by C. bantiana are rarely documented, and an optimal treatment strategy has yet to be established. Given the high fatality rate, an early surgical intervention is crucial for both diagnosis and treatment. The present case was successfully treated with minimally invasive surgical intervention alongside the antifungal combination therapy. (c) 2025 Published by Elsevier Masson SAS on behalf of SFMM.

引用

页数：4

共 19 条

[1] Antifungal therapy of experimental cerebral phaeohyphomycosis due to Cladophialophora bandana [J].