Mechanochemically Enabled Formal Reductive Cross-Coupling Reaction Between Aryl Ethers and Aryl Fluorides

被引：0
作者：
Liu, Tianfen [1 ]
Zhang, Xuemei [1 ]
Wang, Qingqing [1 ]
Lian, Zhong [1 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Dept Dermatol, Chengdu 610041, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年
基金：
中国国家自然科学基金;
关键词：
C & horbar; F cleavage; O cleavage; Cross-coupling; Mechanochemistry; O BOND ACTIVATION; REAGENTS; EXPLORATION; CONVERSION; CLEAVAGE; FORCE; BLUE;
D O I：
10.1002/anie.202424186
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reductive cross-coupling reactions involving two electrophilic reagents have become increasingly important in modern synthetic chemistry. Previous studies have investigated electrophilic reagents featuring zero or one inactive bond; however, reactions involving electrophilic reagents with two inactive bonds remain unexplored. This study presents the first nickel-catalyzed reductive cross-coupling reaction under mechanical conditions, involving aryl ethers and aryl fluorides, both of which contain inactive bonds. The reaction successfully synthesized a series of multifunctional biphenyl compounds, specifically including several sparingly soluble substrates that are challenging to prepare in a solvent system. Mechanistic studies have demonstrated that nickel and magnesium play a crucial role in the activation of C & horbar;F bonds. This novel coupling reaction offers a beneficial approach for polymer degradation and the development of luminescent materials.
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页数：12
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