SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF RUTHENIUM NITROSYL COMPLEXES CONTAINING POLYPYRIDYL LIGANDS

被引:0
|
作者
Penha, Dayana P. S. [1 ]
de Sousa, Thuanny M. [1 ]
de Oliveira, Dayane C. [1 ]
da Silva, Maria R. H. [1 ]
Oliveira, Veronica da S.
Pontes, Daniel de L. [1 ]
Pontes, Ana C. F. de B. [1 ]
Paulo, Tercio de F. [2 ]
da Silva, Francisco O. N. [1 ]
机构
[1] Univ Fed Rio Grande Do Norte UFRN, Inst Quim, Lab Quim Coordenacao & Polimeros LQCPol, BR-59078970 Natal, RN, Brazil
[2] Univ Fed Ceara UFC, Lab Bioinorgan, Dept Quim Organ & Inorgan, Cx Postal 6021, BR-60440900 Fortaleza, CE, Brazil
来源
QUIMICA NOVA | 2025年 / 48卷 / 04期
关键词
nitrosyl complexes; polypyridyl ligands; Pseudomonas aeruginosa; DNA-BINDING PROPERTIES; NITRIC-OXIDE; CRYSTAL-STRUCTURE; II COMPLEXES; NO RELEASE; LIGHT; ELECTROCHEMISTRY; INTERCONVERSION; ANTIOXIDANT; DONOR;
D O I
10.21577/0100-4042.20250098
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The ruthenium(II) complexes cis-[Ru(bpy)(phen)(ImN)(NO)](PF6)3 (I) and cis-[Ru(bpy)(phen)(SO3)(NO)](PF6) (II) (bpy = 2,2'-bipyridine, phen = 1,10'-phenanthroline and ImN = imidazole) were synthesized and characterized using UV-visible, infrared and NMR (nuclear magnetic resonance) spectroscopies and electrochemical techniques. Infrared bands in the 1910-1950 cm-1 range are consistent with NO+ stretching, indicating the coordination of nitric oxide. The UV-Vis results allowed for the identification of intraligand bands of bipyridine and phenanthroline ligands, as well as metal-to-ligand charge transfer (MLCT) bands for both polypyridine ligands in the wavelength range of 320 to 400 nm. Additionally, an MLCT band for the nitrosyl ligand was observed at about 469 nm. The voltammogram profiles displayed a single quasi-reversible process at 219 mV (complex I) and -102 mV (complex II), with both processes being related to the NO+/0 redox pair. The photochemical behavior of these complexes was studied, and NO release was observed upon blue light irradiation. The antibacterial activity of the complexes was tested against the bacteria Staphylococus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa, based on minimum inhibitory concentration measurements, in which no or moderate activity was observed against Gram-positive bacteria. However, complexes I and II showed good antimicrobial activity against Gram-negative Pseudomonas aeruginosa strains, being able to inhibit growth at low concentrations of 57.23 mu mol L-1 for complex I and 200.8 mu mol L-1 for complex II.
引用
收藏
页数:8
相关论文
共 50 条
  • [1] The reactivity of nitrosyl ruthenium complexes containing polypyridyl ligands
    Sauaia, MG
    da Silva, RS
    TRANSITION METAL CHEMISTRY, 2003, 28 (03) : 254 - 259
  • [2] Synthesis, characterization and biological activity of ternary copper(II) complexes containing polypyridyl ligands
    Patel, RN
    Singh, N
    Shukla, KK
    Gundla, VLN
    Chauhan, UK
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2006, 63 (01) : 21 - 26
  • [3] Control of NO release by light irradiation from nitrosyl-ruthenium complexes containing polypyridyl ligands
    Sauaia, MG
    Oliveira, FD
    Tedesco, AC
    da Silva, RS
    INORGANICA CHIMICA ACTA, 2003, 355 : 191 - 196
  • [4] Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes
    Rechitskaya, E. D.
    Kuratieva, N., V
    Lider, E., V
    Eremina, J. A.
    Klyushova, L. S.
    Eltsov, I., V
    Kostin, G. A.
    JOURNAL OF MOLECULAR STRUCTURE, 2020, 1219
  • [5] Novel polypyridyl ruthenium(II) complexes containing oxalamidines as ligands
    Ruben, M
    Rau, S
    Skirl, A
    Krause, K
    Görls, H
    Walther, D
    Vos, JG
    INORGANICA CHIMICA ACTA, 2000, 303 (02) : 206 - 214
  • [6] SYNTHESIS AND CHARACTERIZATION OF NITROSYL COMPLEXES WITH ANTIBACTERIAL ACTION AGAINST Pseudomonas aeruginosa
    de Sousa, Thuanny M.
    Penha, Dayana P. S.
    Pontes, Daniel de L.
    Pontes, Ana C. F. de B.
    da Silva, Francisco O. N.
    QUIMICA NOVA, 2020, 43 (02): : 194 - 200
  • [7] Heterobimetallic Complexes of Polypyridyl Ligands Containing Paramagnetic Centers: Synthesis and Characterization by IR and EPR
    Goforth, Sarah K.
    Walroth, Richard C.
    Brannaka, Joseph A.
    Angerhofer, Alexander
    McElwee-White, Lisa
    INORGANIC CHEMISTRY, 2013, 52 (24) : 14116 - 14123
  • [8] Synthesis and characterisation of ruthenium polypyridyl complexes containing a pendent hydroquinone grouping
    Weldon, FM
    Vos, JG
    INORGANICA CHIMICA ACTA, 2000, 307 (1-2) : 13 - 19
  • [9] Synthesis, Spectroscopic and Electrochemical Properties of Ruthenium (II) Polypyridyl Complexes with Dimethyl-bibenzimidazolate Ligands
    Cao Man-Li
    Shang Mei-Jie
    Liu Wen-Ting
    Yin Wei
    Yao Su-Yang
    Ye Bao-Hui
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2020, 36 (09) : 1763 - 1773
  • [10] Ruthenium(III)-carbonyl and ruthenium(II)-nitrosyl complexes of nitrogen-containing ligands with ethoxysilane groups
    Shi, Li-Miao
    Wang, Xin-Xin
    Ma, Xiu-Fang
    Jia, Ai-Quan
    Zhang, Qian-Feng
    JOURNAL OF COORDINATION CHEMISTRY, 2016, 69 (17) : 2630 - 2636