NFE2L2 and ferroptosis resistance in cancer therapy

被引：13

作者：

Tang, Daolin ^{[1
]}

Kang, Rui ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr, Dept Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

来源：

CANCER DRUG RESISTANCE | 2024年 / 7卷

基金：

美国国家卫生研究院;

关键词：

Cancer therapy; drug resistance; ferroptosis; oxidative stress; TRANSCRIPTION FACTOR NRF2; CELL-DEATH; KEAP1-NRF2; PATHWAY; LIPID-PEROXIDATION; AUTOPHAGY; IDENTIFICATION; GENES; GPX4; INDUCTION; INACTIVATION;

D O I：

10.20517/cdr.2024.123

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a key transcription factor in the cellular defense against oxidative stress, playing a crucial role in cancer cell survival and resistance to therapies. This review outlines the current knowledge on the link between NFE2L2 and ferroptosis - a form of regulated cell death characterized by iron-dependent lipid peroxidation - within cancer cells. While NFE2L2 activation can protect normal cells from oxidative damage, its overexpression in cancer cells contributes to drug resistance by upregulating antioxidant defenses and inhibiting ferroptosis. We delve into the molecular pathways of ferroptosis, highlighting the involvement of NFE2L2 and its target genes, such as NQO1, HMOX1, FTH1, FTL, HERC2, SLC40A1, ferroptosis resistance. Understanding the delicate balance between NFE2L2's protective and deleterious roles could pave the way for novel therapeutic strategies targeting NFE2L2 to enhance the efficacy of ferroptosis inducers in cancer therapy.

引用

页数：24

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