Molecular Characterization of Small Ruminant Lentiviruses in Sheep and Goats: A Systematic Review

被引：0

作者：

Gobbi, Paola ^{[1
,2
]}

Pavone, Silvia ^{[1
]}

Orso, Massimiliano ^{[3
]}

Passamonti, Fabrizio ^{[2
]}

Righi, Cecilia ^{[1
]}

Beato, Maria Serena ^{[1
]}

Feliziani, Francesco ^{[1
]}

Giammarioli, Monica ^{[1
]}

机构：

[1] Ist Zooprofilatt Sperimentale Umbria & Marche Togo, Natl Reference Lab Ruminant Retroviruses, Via G Salvemini 1, I-06126 Perugia, Italy

[2] Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, Italy

[3] Ist Zooprofilatt Sperimentale Umbria & Marche Togo, Special Projects Cooperat & Twinning, Off Res Management, Via G Salvemini 1, I-06126 Perugia, Italy

来源：

ANIMALS | 2024年 / 14卷 / 23期

关键词：

maedi-visna; caev; small ruminant lentivirus; SRLVs; sheep; goats; small ruminants; phylogenesis; molecular characterization; genotyping; ARTHRITIS-ENCEPHALITIS-VIRUS; MAEDI-VISNA-VIRUS; OVINE-PROGRESSIVE-PNEUMONIA; COMPOSITE REFERENCE-STANDARDS; POLYMERASE-CHAIN-REACTION; NATURALLY INFECTED SHEEP; PHYLOGENETIC ANALYSIS; GENETIC-CHARACTERIZATION; RISK-FACTORS; GAG GENE;

D O I：

10.3390/ani14233545

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Small ruminant lentiviruses (SRLVs) are responsible for chronic and progressive multisystemic clinical forms, which significantly reduce flocks' productivity and have a considerable economic impact on the small ruminant industry. Due to the increase in genetic analysis studies and the potential for misclassification of certain strains, owing to the high genetic variability of these viruses, a systematic review was deemed necessary. This review explores the types of matrices used for molecular detection and phylogenetic studies, the genomic regions selected as targets, and the software utilized for phylogenetic analysis, assessing the geographical distribution of identified genotypes and subgenotypes over time. A thorough comparison of the diagnostic approaches highlights the strengths and limitations of each method, identifying gaps that need to be addressed. Additionally, recombination events and compartmentalization are examined to provide an updated, detailed, and comprehensive overview of SRLV phylogenesis.

引用

页数：25

共 185 条

[11] Cellular specificity and replication rate of Maedi Visna virus in vitro can be controlled by LTR sequences [J].