A Very Low-Carbohydrate Program in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease and Phospholipase Domain-Containing Protein 3 Risk Genotype: Pre-Post Intervention Study

被引：0

作者：

Saslow, Laura R. ^{[1
]}

Krinock, Jamie ^{[1
]}

O'Brien, Alison ^{[1
]}

Raymond, Kaitlyn ^{[1
]}

Bayandorian, Hovig

Moskowitz, Judith ^{[2
]}

Daubenmier, Jennifer ^{[3
]}

Oliveri, Antonino ^{[4
]}

Marriott, Deanna J. ^{[5
]}

Griauzde, Dina H. ^{[6
,7
]}

Speliotes, Elizabeth K. ^{[4
,8
]}

机构：

[1] Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, Ann Arbor, MI 48109 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Med Social Sci, Chicago, IL USA

[3] San Francisco State Univ, Inst Holist Hlth Studies, San Francisco, CA USA

[4] Univ Michigan, Med Sch, Dept Internal Med, Div Gastroenterol, Med Sci Bldg 2,Room 4741, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Sch Nursing, Dept Syst Populat & Leadership, Ann Arbor, MI 48109 USA

[6] VA Ann Arbor Healthcare Syst, Ann Arbor, MI USA

[7] Univ Michigan, Med sch, Dept Internal Med, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Med Sch, Gilbert S Omenn Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

来源：

JMIR FORMATIVE RESEARCH | 2025年 / 9卷

关键词：

metabolic dysfunction-associated steatotic liver disease; ketogenic diet; low carbohydrate; adult; genotype; insulin; insulin resistance; metabolic dysfunction; dietary pattern; type; 2; diabetes; T2DM; single-arm pilot trial; liver function test; genome; non-alcoholic fatty liver disease; WEIGHT-LOSS; MEDITERRANEAN DIET; HEPATIC STEATOSIS; LOW-FAT; INDIVIDUALS; SENSITIVITY; OUTCOMES; HEALTH; IMPACT; LIFE;

D O I：

10.2196/60051

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background: Insulin resistance and the G allele of rs738409 interact to create a greater risk of metabolic dysfunction-associated steatotic liver disease. Objective: This study aims to confirm that one promising way to reduce insulin resistance is by following a very low- carbohydrate (VLC) dietary pattern. Methods: Adults with rs738409-GG or-CG with liver steatosis and elevated liver function tests, were taught an ad libitum VLC diet, positive affect and mindful eating skills, goal setting, and self-monitoring and given feedback and coaching for 4 months. We measured liver steatosis, anthropometric, serum metabolic diet adherence, and quality of life measures. Results: In this small pilot trial, of the 11 participants enrolled, 9 (82%) participants completed outcomes. All 11 participants viewed at least 1 session of the intervention, and 8 (73%) participants viewed at least half of the sessions. Among the 9 participants who provided 4-month self-report information, intervention satisfaction was high (mean 6.22, 95% CI 5.58-6.85), with 5 (56%) participants rating the intervention the top score, and 4 (44%) participants reporting they did not plan to stop following the VLC diet. Across participants with a 4-month hepatic liver fat percent measurement, the percent change in liver fat was -33.17% (95% CI -86.48 to 20.14), and in only the participants who were adherent to the eating pattern, the percent change in liver fat was -53.12% (95% CI -71.25 to -34.99). Amongst participants with a 4-month hepatic liver fat percent measurement, 6 out of 8 (75%) participants were considered responders, with a relative decline in liver fat >= 30%, and of the 9 participants with a 4-month body weight, 9 (100%) participants lost >= 5% of their body weight. There were no serious adverse events. Conclusions: Results suggest the feasibility, acceptability, and preliminary efficacy of the VLC intervention in adults with higher genetic risk for metabolic dysfunction-associated steatotic liver disease, although there is a need for further studies given the small sample size and the high risk of substantial biases in this small pilot study.

引用

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