Liquid Biopsy for Spinal Tumors: On the Frontiers of Clinical Application

被引:0
|
作者
Tan, Sze Kiat [1 ]
Bettegowda, Chetan [1 ]
Yip, Stephen [2 ]
Sahgal, Arjun [3 ,4 ]
Rhines, Laurence [5 ]
Reynolds, Jeremy [6 ]
Lazary, Aron [7 ,8 ]
Laufer, Ilya [9 ]
Gasbarrini, Alessandro [10 ]
Dea, Nicolas [11 ]
Verlaan, J. J. [12 ]
Gokaslan, Ziya L. [13 ]
Fisher, Charles G. [11 ]
Boriani, Stefano [14 ]
Cecchinato, Riccardo [14 ]
Goodwin, Matthew L. [15 ]
Goodwin, C. Rory [16 ]
Charest-Morin, Raphaele [11 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD USA
[2] Univ British Columbia, Fac Med, Dept Pathol & Lab Med, Vancouver, BC, Canada
[3] Sunnybrook Odette Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada
[4] Univ Toronto, Dept Radiat Oncol, Toronto, ON, Canada
[5] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA
[6] Univ Oxford, Oxford Spinal Unit, Oxford, England
[7] Semmelweis Univ, Dept Spine Surg, Budapest, Hungary
[8] Semmelweis Univ, Dept Orthopaed Surg, Budapest, Hungary
[9] NYU, Dept Neurosurg, Grossman Sch Med, New York, NY USA
[10] Univ Bologna, Rizzoli Inst, Dept Orthoped Surg, Bologna, Italy
[11] Univ British Columbia, Dept Orthoped, Combined Neurosurg & Orthoped Spine Program, 818 West 10th Ave, Vancouver, BC V5Z 1M9, Canada
[12] Univ Utrecht, Univ Med Ctr Utrecht, Dept Orthoped Surg, Utrecht, Netherlands
[13] Brown Univ, Warren Alpert Med Sch, Dept Neurosurg, Providence, RI USA
[14] IRCCS Galeazzi St Ambrogio Hosp, GSpine4, Milan, Italy
[15] Washington Univ St Louis, Dept Orthoped Surg, St Louis, MO USA
[16] Duke Univ, Med Ctr, Dept Neurosurg, Spine Div, Durham, NC USA
关键词
liquid biopsy; spinal tumors; circulating tumor DNA; blood biomarkers; cerebrospinal fluid biomarker; chordoma; chondrosarcoma; Ewing sarcoma; osteosarcoma; ependymoma; CELL-FREE DNA; CEREBROSPINAL-FLUID; EWING TUMORS; CANCER; BONE; OSTEOSARCOMA; EPENDYMOMAS; MUTATIONS; BIOMARKER; FREQUENT;
D O I
10.1177/21925682231222012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study DesignNarrative review.ObjectivesThis article aims to provide a narrative review of the current state of research for liquid biopsy in spinal tumors and to discuss the potential application of liquid biopsy in the clinical management of patients with spinal tumors.MethodsA comprehensive review of the literature was performed using PubMed, Google Scholar, Medline, Embase and Cochrane databases, and the review was limited to articles of English language. All the relevant articles which were identified to be related to liquid biomarker study in spinal tumors, were studied in full text.ResultsLiquid biopsy has revolutionized the field of precision medicine by guiding personalized clinical management of cancer patients based on the liquid biomarker status. In recent years, more research has been done to investigate its potential utilization in patients with tumors from the spine. Herein, we review the liquid biomarkers that have been proposed in different spine malignancies including chordoma, chondrosarcoma, Ewing sarcoma, osteosarcoma, astrocytoma and ependymoma. We also discuss the wide window of opportunity to utilize these liquid biomarkers in diagnosis, treatment response, monitoring, and detection of minimal residual disease in patients with spinal tumors.ConclusionsLiquid biomarkers, especially blood-derived circulating tumor DNA, has a promising clinical utility as they are disease-specific, minimally invasive, and the procedure is repeatable. Prospective studies with larger populations are needed to fully establish its use in the setting of spinal tumors.
引用
收藏
页码:16S / 28S
页数:13
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