Traditional Chinese herbal medicine: harnessing dendritic cells for anti-tumor benefits

被引：1
|
作者：
Shen, Mengyi [1 ,2 ,3 ,4 ,5 ]
Li, Zhen [6 ]
Wang, Jing [4 ,5 ,7 ]
Xiang, Hongjie [4 ,5 ]
Xie, Qi [1 ,2 ]
机构：
[1] Shandong First Med Univ, Dept Oncol, Affiliated Hosp 1, Jinan, Peoples R China
[2] Shandong Prov Qianfoshan Hosp, Shandong Lung Canc Inst, Jinan, Peoples R China
[3] Shandong First Med Univ & Shandong Acad Med Sci, Jinan, Peoples R China
[4] Shandong First Med Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Jinan, Peoples R China
[5] Shandong Prov Qianfoshan Hosp, Jinan, Peoples R China
[6] Shandong First Med Univ & Shandong Acad Med Sci, Sch Prevent Med Sci, Jinan, Peoples R China
[7] Shandong Second Med Univ, Coll Tradit Chinese Med, Weifang, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
Chinese herbal medicine; dendritic cells; maturation; anti-tumor; immunity; TOLL-LIKE RECEPTORS; LYCIUM-BARBARUM POLYSACCHARIDES; HOCHU-EKKI-TO; EPIMEDIUM POLYSACCHARIDE; CANCER-IMMUNOTHERAPY; SIGNAL-TRANSDUCTION; HERICIUM ERINACEUS; PLGA NANOPARTICLES; CELLULAR-IMMUNITY; MATURATION;
D O I：
10.3389/fimmu.2024.1408474
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chinese Herbal Medicine (CHM) is being more and more used in cancer treatment because of its ability to regulate the immune system. Chinese Herbal Medicine has several advantages over other treatment options, including being multi-component, multi-target, and having fewer side effects. Dendritic cells (DCs) are specialized antigen presenting cells that play a vital part in connecting the innate and adaptive immune systems. They are also important in immunotherapy. Recent evidence suggests that Chinese Herbal Medicine and its components can positively impact the immune response by targeting key functions of dendritic cells. In this review, we have summarized the influences of Chinese Herbal Medicine on the immunobiological feature of dendritic cells, emphasized an anti-tumor effect of CHM-treated DCs, and also pointed out deficiencies in the regulation of DC function by Chinese Herbal Medicine and outlined future research directions.
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页数：15
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