Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries

被引：0
|
作者：
Ucar, Okan [1 ]
Ozturk, Ibrahim I. [1 ]
Grzeskiewicz, Anita M. [2 ]
Kubicki, Maciej [2 ]
Banti, Christina [3 ]
Hadjikakou, Sotiris K. [3 ,4 ]
机构：
[1] Tekirdag Namik Kemal Univ, Dept Chem, Sect Inorgan Chem, TR-59030 Tekirdag, Turkiye
[2] Adam Mickiewicz Univ, Dept Chem, Ul Umultowska 89b, PL-61614 Poznan, Poland
[3] Univ Ioannina, Dept Chem, Sect Inorgan & Analyt Chem, Ioannina 45110, Greece
[4] Univ Res Ctr Ioannina URCI, Inst Mat Sci & Comp, Ioannina, Greece
来源：
INORGANICA CHIMICA ACTA | 2025年 / 581卷
关键词：
acetylthiophene thiosemicarbazone; Anticancer activity; Antimicrobial activity; Antimony(III); Crystal structure; HIRSHFELD SURFACE-ANALYSIS; ANTITUMOR-ACTIVITY; METAL-COMPLEXES; SEMICARBAZONES; DERIVATIVES; ANTIFUNGAL; BISMUTH;
D O I：
10.1016/j.ica.2025.122627
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr2(kappa 2-N3, S-Hatetsc)]} (1) and {[SbCl2(eta 1-S-Hatmtsc)(kappa 2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.
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页数：10
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