Sex-and brain region-specific alterations in brain volume in germ-free mice

被引：0
作者：
Thompson, Shawna L. [1 ]
Ellegood, Jacob [2 ]
Bowdish, Dawn M. E. [3 ,4 ]
Lerch, Jason P. [2 ,5 ]
Foster, Jane A. [1 ,6 ,7 ]
机构：
[1] McMaster Univ, Psychiat & Behav Neurosci, Hamilton, ON, Canada
[2] Hosp Sick Children, Mouse Imaging Ctr, Toronto, ON, Canada
[3] McMaster Univ, Dept Med, Hamilton, ON, Canada
[4] McMaster Univ, McMaster Immunol Res Ctr, Hamilton, ON, Canada
[5] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci, FMRIB, Oxford, England
[6] Res Inst St Joes Hamilton, Hamilton, ON, Canada
[7] Univ Texas Southwestern Med Ctr, Ctr Depress Res & Clin Care, Dept Psychiat, Dallas, TX 75390 USA
来源：
ISCIENCE | 2024年 / 27卷 / 12期
关键词：
GUT MICROBIOTA; STRESS-RESPONSE; MOUSE; EXPRESSION; IMAGE; MRI; SEGMENTATION; REGISTRATION; MICROGLIA; ABSENCE;
D O I：
10.1016/j.isci.2024.111429
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several lines of evidence demonstrate that microbiota influence brain development. Using high-resolution ex vivo magnetic resonance imaging (MRI), this study examined the impact of microbiota status on brain volume and revealed microbiota-related differences that were sex and brain region dependent. Cortical and hippocampal regions demonstrate increased sensitivity to microbiota status during the first 5 weeks of postnatal life, effects that were greater in male germ-free mice. Conventionalization of germ-free mice at puberty did not normalize brain volume changes. These data add to the existing literature and highlight the need to focus more attention on early-life microbiota-brain axis mechanisms in order to understand the regulatory role of the microbiome in brain development.
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页数：11
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