Sex-and brain region-specific alterations in brain volume in germ-free mice

被引：0
作者：
Thompson, Shawna L. [1 ]
Ellegood, Jacob [2 ]
Bowdish, Dawn M. E. [3 ,4 ]
Lerch, Jason P. [2 ,5 ]
Foster, Jane A. [1 ,6 ,7 ]
机构：
[1] McMaster Univ, Psychiat & Behav Neurosci, Hamilton, ON, Canada
[2] Hosp Sick Children, Mouse Imaging Ctr, Toronto, ON, Canada
[3] McMaster Univ, Dept Med, Hamilton, ON, Canada
[4] McMaster Univ, McMaster Immunol Res Ctr, Hamilton, ON, Canada
[5] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci, FMRIB, Oxford, England
[6] Res Inst St Joes Hamilton, Hamilton, ON, Canada
[7] Univ Texas Southwestern Med Ctr, Ctr Depress Res & Clin Care, Dept Psychiat, Dallas, TX 75390 USA
来源：
ISCIENCE | 2024年 / 27卷 / 12期
关键词：
GUT MICROBIOTA; STRESS-RESPONSE; MOUSE; EXPRESSION; IMAGE; MRI; SEGMENTATION; REGISTRATION; MICROGLIA; ABSENCE;
D O I：
10.1016/j.isci.2024.111429
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several lines of evidence demonstrate that microbiota influence brain development. Using high-resolution ex vivo magnetic resonance imaging (MRI), this study examined the impact of microbiota status on brain volume and revealed microbiota-related differences that were sex and brain region dependent. Cortical and hippocampal regions demonstrate increased sensitivity to microbiota status during the first 5 weeks of postnatal life, effects that were greater in male germ-free mice. Conventionalization of germ-free mice at puberty did not normalize brain volume changes. These data add to the existing literature and highlight the need to focus more attention on early-life microbiota-brain axis mechanisms in order to understand the regulatory role of the microbiome in brain development.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Brain region-specific myelinogenesis is not directly linked to amyloid-? in APP/PS1 transgenic mice
    Wu, Shuang-Ling
    Yu, Bin
    Cheng, Yong-Jie
    Ren, Shu-Yu
    Wang, Fei
    Xiao, Lan
    Chen, Jing-Fei
    Mei, Feng
    EXPERIMENTAL NEUROLOGY, 2023, 362
  • [32] Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure
    Brandi, Edoardo
    Torres-Garcia, Laura
    Svanbergsson, Alexander
    Haikal, Caroline
    Liu, Di
    Li, Wen
    Li, Jia-Yi
    FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [33] Brain region-specific gene expression profiles in freshly isolated rat microglia
    Doorn, Karlijn J.
    Breve, John J. P.
    Drukarch, Benjamin
    Boddeke, Hendrikus W.
    Huitinga, Inge
    Lucassen, Paul J.
    van Dam, Anne-Marie
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
  • [34] BRAIN ACETYLCHOLINE AND CHOLINE CONCENTRATIONS AND DYNAMICS IN A MURINE MODEL OF THE FRAGILE X SYNDROME: AGE, SEX AND REGION-SPECIFIC CHANGES
    Scremin, O. U.
    Roch, M.
    Norman, K. M.
    Djazayeri, S.
    Liu, Y. -Y.
    NEUROSCIENCE, 2015, 301 : 520 - 528
  • [35] Genetic architecture of subcortical brain regions: common and region-specific genetic contributions
    Renteria, M. E.
    Hansell, N. K.
    Strike, L. T.
    McMahon, K. L.
    de Zubicaray, G. I.
    Hickie, I. B.
    Thompson, P. M.
    Martin, N. G.
    Medland, S. E.
    Wright, M. J.
    GENES BRAIN AND BEHAVIOR, 2014, 13 (08) : 821 - 830
  • [36] Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice
    Hill, Rachel A.
    van den Buuse, Maarten
    BRAIN RESEARCH, 2011, 1384 : 51 - 60
  • [37] Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice
    Jin, Chunmei
    Kang, Hyojin
    Ryu, Jae Ryun
    Kim, Shinhyun
    Zhang, Yinhua
    Lee, Yeunkum
    Kim, Yoonhee
    Han, Kihoon
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 11
  • [38] Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior
    Luczynski, Pauline
    Neufeld, Karen-Anne McVey
    Oriach, Clara Seira
    Clarke, Gerard
    Dinan, Timothy G.
    Cryan, John F.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2016, 19 (08) : 1 - 17
  • [39] Region-specific reductions in brain apparent diffusion coefficient in cytomegalovirus-infected fetuses
    Yaniv, G.
    Hoffmann, C.
    Weisz, B.
    Lipitz, S.
    Katorza, E.
    Kidron, D.
    Bergman, D.
    Biegon, A.
    ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2016, 47 (05) : 600 - 607
  • [40] Age-Dependent Sex Differences in Perineuronal Nets in an APP Mouse Model of Alzheimer's Disease Are Brain Region-Specific
    Rahmani, Rayane
    Rambarack, Naiomi
    Singh, Jaijeet
    Constanti, Andrew
    Ali, Afia B.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
12345