Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia

被引：0

作者：

Poortman, Simon R. ^{[1
]}

Jamarik, Jakub ^{[1
,2
]}

van der Beek, Louise ten Harmsen ^{[1
]}

Setiaman, Nikita ^{[1
,3
]}

Hillegers, Manon H. J. ^{[1
,3
]}

Barendse, Marjolein E. A. ^{[1
]}

van Haren, Neeltje E. M. ^{[1
,3
]}

机构：

[1] Erasmus MC, Sophia Childrens Hosp, Dept Child & Adolescent Psychiat Psychol, KP2,Wytemaweg 8, NL-3015 CN Rotterdam, Netherlands

[2] Masaryk Univ, Fac Med, Brno, Czech Republic

[3] Univ Med Ctr Utrecht, Brain Ctr, Dept Psychiat, Utrecht, Netherlands

来源：

DEVELOPMENTAL COGNITIVE NEUROSCIENCE | 2025年 / 72卷

关键词：

Bipolar disorder; Gyrification; High familial risk; Longitudinal; Offspring; Schizophrenia; HUMAN CEREBRAL-CORTEX; MENTAL-DISORDERS; PSYCHOTIC DISORDERS; LIFETIME PREVALENCE; CORTICAL THICKNESS; SEX-DIFFERENCES; INDIVIDUALS; SURFACE; METAANALYSIS; CONVERSION;

D O I：

10.1016/j.dcn.2025.101536

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Offspring of parents with severe mental illness are at increased risk of developing psychopathology. Identifying endophenotypic markers in high-familial-risk individuals can aid in early detection and inform development of prevention strategies. Using generalized additive mixed models, we compared age trajectories of gyrification index (GI) and sulcal morphometric measures (i.e., sulcal depth, length and width) between individuals at familial risk for bipolar disorder or schizophrenia and controls. 300 T1-weighted MRI scans were obtained of 187 individuals (53 % female, age range: 8-23 years) at familial risk for bipolar disorder (n = 80, n families=55) or schizophrenia (n = 53, n families=36) and controls (n = 54, n families=33). 113 individuals underwent two scans. Globally, GI, sulcal depth and sulcal length decreased significantly with age, and sulcal width increased significantly with age in a (near-)linear manner. There were no differences between groups in age trajectories or mean values of gyrification or any of the sulcal measures. These findings suggest that, on average, young individuals at familial risk for bipolar disorder or schizophrenia have preserved developmental patterns of gyrification and sulcal morphometrics during childhood and adolescence.

引用

页数：12