The Microbiota-Gut-Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease

被引:0
|
作者
Nassir, Che Mohd Nasril Che Mohd [1 ]
Ramli, Muhammad Danial Che [2 ]
Ghazali, Mazira Mohamad [1 ,3 ]
Jaffer, Usman [4 ]
Hamid, Hafizah Abdul [5 ]
Mehat, Muhammad Zulfadli [5 ]
Hein, Zaw Myo [6 ]
机构
[1] Univ Sultan Zainal Abidin, Fac Med, Sch Basic Med Sci, Dept Anat & Physiol, Kuala Terengganu 20400, Terengganu, Malaysia
[2] Management & Sci Univ, Fac Hlth & Life Sci, Shah Alam 40150, Selangor, Malaysia
[3] Univ Sains Malaysia, Sch Med Sci, Dept Neurosci, Kubang Kerian 16150, Kelantan, Malaysia
[4] Int Islamic Univ Malaysia, Kulliyyah Islamic Revealed Knowledge & Human Sci, Kuala Lumpur 50728, Malaysia
[5] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Selangor, Malaysia
[6] Ajman Univ, Coll Med, Dept Basic Med Sci, POB 346, Ajman, U Arab Emirates
来源
LIFE-BASEL | 2025年 / 15卷 / 01期
关键词
microbiota; gut-brain axis; microparticles; cerebral small vessel disease; sleep; glymphatic system; RISK-FACTORS; FATTY-ACIDS; HEALTH; SLEEP; MICROPARTICLES; PATHOGENESIS; DYSBIOSIS; RESPONSES; GENETICS; IMPACT;
D O I
10.3390/life15010003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The human microbiota constitute a very complex ecosystem of microorganisms inhabiting both the inside and outside of our bodies, in which health maintenance and disease modification are the main regulatory features. The recent explosion of microbiome research has begun to detail its important role in neurological health, particularly concerning cerebral small vessel disease (CSVD), a disorder associated with cognitive decline and vascular dementia. This narrative review represents state-of-the-art knowledge of the intimate, complex interplay between microbiota and brain health through the gut-brain axis (GBA) and the emerging role of glymphatic system dysfunction (glymphopathy) and circulating cell-derived microparticles (MPs) as mediators of these interactions. We discuss how microbial dysbiosis promotes neuroinflammation, vascular dysfunction, and impaired waste clearance in the brain, which are critical factors in the pathogenesis of CSVD. Further, we discuss lifestyle factors that shape the composition and functionality of the microbiota, focusing on sleep as a modifiable risk factor in neurological disorders. This narrative review presents recent microbiome research from a neuroscientific and vascular perspective to establish future therapeutic avenues in targeting the microbiota to improve brain health and reduce the burden of CSVD.
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页数:28
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