On the Use of Strong Proton Donors as a Tool for Overcoming Line Broadening in NMR: A Comment

被引：2

作者：

Charisiadis, Pantelis ^{[1
]}

Venianakis, Themistoklis ^{[1
]}

Papaemmanouil, Christina D. ^{[1
]}

Primikyri, Alexandra ^{[1
]}

Tzakos, Andreas G. ^{[1
]}

Siskos, Michael G. ^{[1
]}

Gerothanassis, Ioannis P. ^{[1
]}

机构：

[1] Univ Ioannina, Dept Chem, Sect Organ Chem & Biochem, Ioannina, Greece

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2025年 / 63卷 / 03期

关键词：

H-1-C-13; HMBC; 2,2,2-trifluoroacetic acid (TFA); labile protons; line broadening; picric acid (2,4,6-trinitropnenol); AB-INITIO CALCULATIONS; CHEMICAL-SHIFTS; HYDROXYL PROTONS; HYDROGEN-BONDS; AQUEOUS-SOLUTIONS; H-1-NMR; SPECTROSCOPY; H-1; ELUCIDATION; PREDICTION;

D O I：

10.1002/mrc.5499

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Overcoming line broadening of labile protons and achieving high-resolution NMR spectra is crucial for the structural and conformational analysis of organic molecules. Recently, Ma et al. (Magn. Reson. Chem. 2024, 62, 198-207) demonstrated the effectiveness of 2,2,2-trifluoroacetic acid (TFA) in sharpening NMR signals for nitrogen-containing compounds which exhibit prototropic tautomerization or conformational isomerism using high molar ratio of [acids]/[solute] similar to 5 to 200. In this commentary, we provide an overview of earlier publications and highlight the extensive applications of TFA in enhancing NMR resolution across a variety of organic functional groups, with the use of very small ratios of [acids]/[solute] similar to 10(-3) to 10(-2). The prospects for the unequivocal structure analysis using labile protons as the starting point will be analyzed.

引用

页码：170 / 179

页数：10