One-Pot Synthesis of 3-Hydroxy-1H-Pyrrolo[3,4-b]quinolin-1-one via Enaminamides

被引：0

作者：

Shen, Xi ^{[1
]}

Yu, Zhi-Cheng ^{[1
]}

Zhou, You ^{[1
]}

Wu, Yan-Dong ^{[1
]}

Wu, An-Xin ^{[1
,2
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Multicomponent cascade cyclization; Enaminamide reagents; One-pot; Good substrate compatibility; FUNGUS VERTICILLIUM-HEMIPTERIGENUM; BIOSYNTHETIC GENE-CLUSTER;

D O I：

10.1002/adsc.202400591

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A multicomponent cascade cyclization reaction using aryl methyl ketones, aryl amines, and enaminamide reagents to construct 3-hydroxy-1H-pyrrolo[3,4-b]quinolin-1-one skeleton with good substrate compatibility (50 examples) has been reported. The one-pot, metal-free process formed two C-C bonds, two C-N bonds, and a tetrasubstituted carbon stereocenter containing a hydroxyl group. The reaction enabled modified transformation of drug molecules and derivatization of products.

引用

页码：4399 / 4403

页数：5

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