Progress in African Swine Fever Vector Vaccine Development

被引:0
|
作者
Yang, Yue [1 ]
Yuan, Hengxing [1 ]
Zhang, Yulu [1 ]
Luan, Ji [1 ]
Wang, Hailong [1 ]
机构
[1] Shandong Univ, Helmholtz Inst Biotechnol, Helmholtz Int Lab Antiinfect, State Key Lab Microbial Technol,Inst Microbial Te, Qingdao 266237, Peoples R China
关键词
African swine fever; vaccines; ASFV antigens; vectors; cytokines; AVIAN INFLUENZA-VIRUS; PSEUDORABIES VIRUS; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; LACTOCOCCUS-LACTIS; IMMUNE-RESPONSES; DELIVERY-SYSTEMS; DOMESTIC PIGS; I INTERFERON; PROTEIN;
D O I
10.3390/ijms26030921
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
African swine fever (ASF) is a highly lethal, infectious, hemorrhagic fever disease, characterized by an acute mortality rate approaching 100%. It is highly contagious, and results in significant losses to the global hog industry as it spreads. Despite incremental progress in research on the African swine fever virus (ASFV), a safe and effective commercial vaccine has yet to be developed. Vector vaccines, a promising type of vaccine, offer unique advantages, and are a primary focus in ASFV vaccine research. This paper focuses on the characteristics of viral, bacterial, and yeast vector vaccines; elucidates the immunological mechanisms associated with antigens; lists the types of antigens that have significant potential; discusses the feasibility of using exogenously expressed cytokines to enhance the protective power of vector vaccines; and, finally, discusses the types of vectors that are commonly used and the latest advances in this field.
引用
收藏
页数:24
相关论文
共 50 条
  • [31] Swine fever: classical swine fever and African swine fever
    Kleiboeker, SB
    VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE, 2002, 18 (03) : 431 - +
  • [32] African swine fever vaccines: a promising work still in progress
    Laia Bosch-Camós
    Elisabeth López
    Fernando Rodriguez
    Porcine Health Management, 6
  • [33] African swine fever vaccines: a promising work still in progress
    Bosch-Camos, Laia
    Lopez, Elisabeth
    Rodriguez, Fernando
    PORCINE HEALTH MANAGEMENT, 2020, 6 (01)
  • [34] Host immune responses against African swine fever virus: Insights and challenges for vaccine development
    Orosco, Fredmoore L.
    OPEN VETERINARY JOURNAL, 2023, 13 (12) : 1517 - 1535
  • [35] Immunoinformatics Based Development of A Multi-epitope Vaccine Against African Swine Fever Virus
    Fagbohun, Olusegun
    FASEB JOURNAL, 2021, 35
  • [36] Surveillance Working Group makes progress, funds multiple African swine fever and classical swine fever projects
    不详
    JOURNAL OF SWINE HEALTH AND PRODUCTION, 2021, 29 (01): : 37 - 37
  • [37] African swine fever
    Penrith, Mary-Louise
    ONDERSTEPOORT JOURNAL OF VETERINARY RESEARCH, 2009, 76 (01) : 91 - 95
  • [38] AFRICAN SWINE FEVER
    MEBUS, CA
    ADVANCES IN VIRUS RESEARCH, 1988, 35 : 251 - 269
  • [39] African swine fever
    不详
    MAGYAR ALLATORVOSOK LAPJA, 2014, 136 (06) : 335 - 338
  • [40] African Swine Fever
    Bundschuh, M.
    Gerber, A.
    ZENTRALBLATT FUR ARBEITSMEDIZIN ARBEITSSCHUTZ UND ERGONOMIE, 2014, 64 (02): : 117 - 118