Progress in African Swine Fever Vector Vaccine Development

被引:0
|
作者
Yang, Yue [1 ]
Yuan, Hengxing [1 ]
Zhang, Yulu [1 ]
Luan, Ji [1 ]
Wang, Hailong [1 ]
机构
[1] Shandong Univ, Helmholtz Inst Biotechnol, Helmholtz Int Lab Antiinfect, State Key Lab Microbial Technol,Inst Microbial Te, Qingdao 266237, Peoples R China
关键词
African swine fever; vaccines; ASFV antigens; vectors; cytokines; AVIAN INFLUENZA-VIRUS; PSEUDORABIES VIRUS; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; LACTOCOCCUS-LACTIS; IMMUNE-RESPONSES; DELIVERY-SYSTEMS; DOMESTIC PIGS; I INTERFERON; PROTEIN;
D O I
10.3390/ijms26030921
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
African swine fever (ASF) is a highly lethal, infectious, hemorrhagic fever disease, characterized by an acute mortality rate approaching 100%. It is highly contagious, and results in significant losses to the global hog industry as it spreads. Despite incremental progress in research on the African swine fever virus (ASFV), a safe and effective commercial vaccine has yet to be developed. Vector vaccines, a promising type of vaccine, offer unique advantages, and are a primary focus in ASFV vaccine research. This paper focuses on the characteristics of viral, bacterial, and yeast vector vaccines; elucidates the immunological mechanisms associated with antigens; lists the types of antigens that have significant potential; discusses the feasibility of using exogenously expressed cytokines to enhance the protective power of vector vaccines; and, finally, discusses the types of vectors that are commonly used and the latest advances in this field.
引用
收藏
页数:24
相关论文
共 50 条
  • [21] Multifaceted Immune Responses to African Swine Fever Virus: Implications for Vaccine Development
    Wang, Tao
    Sun, Yuan
    Huang, Shujian
    Qiu, Hua-Ji
    VETERINARY MICROBIOLOGY, 2020, 249
  • [22] Progress Toward Development of Effective and Safe African Swine Fever Virus Vaccines
    Sang, Huldah
    Miller, Gabrielle
    Lokhandwala, Shehnaz
    Sangewar, Neha
    Waghela, Suryakant D.
    Bishop, Richard P.
    Mwangi, Waithaka
    FRONTIERS IN VETERINARY SCIENCE, 2020, 7
  • [23] Development of African Swine Fever in Poland
    Szymanska, Elzbieta Jadwiga
    Dziwulaki, Mariusz
    AGRICULTURE-BASEL, 2022, 12 (01):
  • [24] Development of a pandemic of African Swine Fever
    Pejsak, Zygmunt
    Truszczynski, Marian
    Tarasiuk, Kazimierz
    MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE, 2019, 75 (02): : 88 - 92
  • [25] African swine fever vaccine: Turning a dream into reality
    Munoz-Perez, Carolina
    Jurado, Cristina
    Sanchez-Vizcaino, Jose Manuel
    TRANSBOUNDARY AND EMERGING DISEASES, 2021, 68 (05) : 2657 - 2668
  • [26] One step closer to African swine fever vaccine
    Loeb, Josh
    VETERINARY RECORD, 2020, 186 (18) : 585 - 585
  • [27] African Swine Fever Virus Biology and Vaccine Approaches
    Revilla, Yolanda
    Perez-Nunez, Daniel
    Richt, Juergen A.
    ADVANCES IN VIRUS RESEARCH, VOL 100, 2018, 100 : 41 - 74
  • [28] Subunit Vaccine Approaches for African Swine Fever Virus
    Gaudreault, Natasha N.
    Richt, Juergen A.
    VACCINES, 2019, 7 (02)
  • [29] USDA DEVELOPS CANDIDATE AFRICAN SWINE FEVER VACCINE
    Cima, Greg
    JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2021, 259 (01): : 23 - 23
  • [30] Commentary: An Urgent Need for an African Swine Fever Vaccine
    Woodland, David L.
    VIRAL IMMUNOLOGY, 2020, 33 (02) : 71 - 71