Progress in African Swine Fever Vector Vaccine Development

被引:0
|
作者
Yang, Yue [1 ]
Yuan, Hengxing [1 ]
Zhang, Yulu [1 ]
Luan, Ji [1 ]
Wang, Hailong [1 ]
机构
[1] Shandong Univ, Helmholtz Inst Biotechnol, Helmholtz Int Lab Antiinfect, State Key Lab Microbial Technol,Inst Microbial Te, Qingdao 266237, Peoples R China
关键词
African swine fever; vaccines; ASFV antigens; vectors; cytokines; AVIAN INFLUENZA-VIRUS; PSEUDORABIES VIRUS; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; LACTOCOCCUS-LACTIS; IMMUNE-RESPONSES; DELIVERY-SYSTEMS; DOMESTIC PIGS; I INTERFERON; PROTEIN;
D O I
10.3390/ijms26030921
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
African swine fever (ASF) is a highly lethal, infectious, hemorrhagic fever disease, characterized by an acute mortality rate approaching 100%. It is highly contagious, and results in significant losses to the global hog industry as it spreads. Despite incremental progress in research on the African swine fever virus (ASFV), a safe and effective commercial vaccine has yet to be developed. Vector vaccines, a promising type of vaccine, offer unique advantages, and are a primary focus in ASFV vaccine research. This paper focuses on the characteristics of viral, bacterial, and yeast vector vaccines; elucidates the immunological mechanisms associated with antigens; lists the types of antigens that have significant potential; discusses the feasibility of using exogenously expressed cytokines to enhance the protective power of vector vaccines; and, finally, discusses the types of vectors that are commonly used and the latest advances in this field.
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页数:24
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