A Facile Synthesis of Some Bioactive Isoxazoline Dicarboxylic Acids via Microwave-Assisted 1,3-Dipolar Cycloaddition Reaction

被引：0

作者：

Master, Jessica ^{[1
]}

Sydney, Shekiel ^{[1
]}

Rajapaske, Harsha ^{[1
]}

Saffiddine, Malek ^{[1
]}

Reyes, Vikiana ^{[1
]}

Denton, Richard W. ^{[1
]}

机构：

[1] CUNY, MEDGAR EVERS COLL, NEW YORK, NY 10017 USA

来源：

REACTIONS | 2024年 / 5卷 / 04期

关键词：

microwave-assisted 1,3-dipolar cycloaddition reaction; isoxazoline; antibiotics; saponofication;

D O I：

10.3390/reactions5040057

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The microwave-assisted 1,3-dipolar cycloaddition reaction of several aldoximes and dimethyl-2-methylene glutarate in the presence of diacetoxyiodobenzene as an oxidant produced four new isoxazoline-derived dimethyl carboxylates. Saponification followed by acidification of the latter yielded novel isoxazoline dicarboxylic acids in reasonable to high yields. The structures of these novel compounds were characterized by IR, 1H-NMR, 13C-NMR, and HRMS spectroscopy. Their biological activities disclosed higher inhibition of the growth of E. coli organisms by the aromatic compounds than by the aliphatic derivatives, demonstrating their potential in antibiotics research.

引用

页码：1080 / 1088

页数：9

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