[1] Univ St Andrews, Sch Med, St Andrews, Scotland
[2] NHS Fife, Kirkcaldy, Scotland
[3] NHS Tayside, Dundee, Scotland
[4] Univ Edinburgh, Adv Care Res Ctr, Edinburgh, Scotland
[5] Univ Coll London Hosp NHS Fdn Trust, London, England
[6] Univ Edinburgh, Edinburgh Clin Trials Unit, Edinburgh, Scotland