Recent Advances in Development of Bioactive Fluorinated Pyrazole Derivatives: A Review

Fluorine, the most electronegative element, is currently used extensively in medicine, agrochemistry, and material science. Fluorinated compounds are expected to account for 30-50% of all active components now under development. It is difficult for medicinal chemists to discover new active compounds with higher efficacy, decreased mammalian toxicity, a better environmental profile, and a cheaper cost; yet, fluorinated pyrazole fits all of these criteria. The current review will provide an overview of the synthesis of pyrazoles with novel fluorinated substituents that have important uses in pharmaceutical and agricultural chemistry, with a focus on data published between 2011 and 2023. A concise table with the relevant literature references helped the reader to understand each derivative of fluorinated pyrazoles according to their biological activity.