Cap-specific m6Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy

被引：0

作者：

Akichika, Shinichiro ^{[1
]}

Suzuki, Tsutomu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Tokyo, Japan

来源：

MOLECULAR CELL | 2024年 / 84卷 / 21期

关键词：

D O I：

10.1016/j.molcel.2024.10.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Molecular Cell, An et al. reports a novel function of cap-specific m(6)Am modification acting as an anti-terminator for premature RNA polymerase II transcription by sequestering a transcriptional terminator PCF11. This study provides new insights into RNA modifications in transcriptional control and cancer treatment.

引用

页码：4051 / 4052

页数：2

共 11 条

[1] Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase
Akichika, Shinichiro
Hirano, Seiichi
Shichino, Yuichi
Suzuki, Takeo
Nishimasu, Hiroshi
Ishitani, Ryuichiro
Sugita, Ai
Hirose, Yutaka
Iwasaki, Shintaro
Nureki, Osamu
Suzuki, Tsutomu
[J]. SCIENCE, 2019, 363 (6423) : 141 - 141
[2] m6Am sequesters PCF11 to suppress premature termination and drive neuroblastoma differentiation
An, Huihui
Hong, Yifan
Goh, Yeek Teck
Koh, Casslynn W. Q.
Kanwal, Shahzina
Zhang, Yi
Lu, Zhaoqi
Yap, Phoebe M. L.
Neo, Suat Peng
Wong, Chun-Ming
Wong, Alice S. T.
Yu, Yang
Ho, Jessica Sook Yuin
Gunaratne, Jayantha
Goh, Wee Siong Sho
[J]. MOLECULAR CELL, 2024, 84 (21) : 4142 - 4157.e14
[3] Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome
Boulias, Konstantinos
Toczydlowska-Socha, Diana
Hawley, Ben R.
Liberman, Noa
Takashima, Ken
Zaccara, Sara
Guez, Theo
Vasseur, Jean-Jacques
Debart, Francoise
Aravind, L.
Jaffrey, Samie R.
Greer, Eric Lieberman
[J]. MOLECULAR CELL, 2019, 75 (03) : 631 - +
[4] Regulation of m6Am RNA modification and its implications in human diseases
Jin, Hao
Shi, Zhouyuanjing
Zhou, Tianhua
Xie, Shanshan
[J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2024, 16 (03)
[5] The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
Pandey, Radha Raman
Delfino, Elena
Homolka, David
Roithova, Adriana
Chen, Kuan-Ming
Li, Lingyun
Franco, Giulia
Vagbo, Cathrine Broberg
Taillebourg, Emmanuel
Fauvarque, Marie-Odile
Pillai, Ramesh S.
[J]. CELL REPORTS, 2020, 32 (07):
[6] FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Relier, Sebastien
Ripoll, Julie
Guillorit, Helene
Amalric, Amandine
Achour, Cyrinne
Boissiere, Florence
Vialaret, Jerome
Attina, Aurore
Debart, Francoise
Choquet, Armelle
Macari, Francoise
Marchand, Virginie
Motorin, Yuri
Samalin, Emmanuelle
Vasseur, Jean-Jacques
Pannequin, Julie
Aguilo, Francesca
Lopez-Crapez, Evelyne
Hirtz, Christophe
Rivals, Eric
Bastide, Amandine
David, Alexandre
[J]. NATURE COMMUNICATIONS, 2021, 12 (01)
[7] PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression
Sendinc, Erdem
Valle-Garcia, David
Dhall, Abhinav
Chen, Hao
Henriques, Telmo
Navarrete-Perea, Jose
Sheng, Wanqiang
Gygi, Steven P.
Adelman, Karen
Shi, Yang
[J]. MOLECULAR CELL, 2019, 75 (03) : 620 - +
[8] Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase
Sun, Hanxiao
Zhang, Meiling
Li, Kai
Bai, Dongsheng
Yi, Chengqi
[J]. CELL RESEARCH, 2019, 29 (01) : 80 - 82
[9] Methylation of viral mRNA cap structures by PCIF1 attenuates the antiviral activity of interferon-β
Tartell, Michael A.
Boulias, Konstantinos
Hoffmann, Gabriela Brunsting
Bloyet, Louis-Marie
Greer, Eric Lieberman
Whelan, Sean P. J.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (29)
[10] N6,O2'-DIMETHYLADENOSINE A NOVEL METHYLATED RIBONUCLEOSIDE NEXT TO 5' TERMINAL OF ANIMAL-CELL AND VIRUS MESSENGER-RNAS
WEI, CM
GERSHOWITZ, A
MOSS, B
[J]. NATURE, 1975, 257 (5523) : 251 - 253

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