A novel application of neurite orientation dispersion and density imaging to differentiate cognitively recovered versus non-recovered following mild traumatic brain injury

被引：0
作者：
Swaminathan, Prasath [1 ]
Hamzah, Norhamizan [2 ]
Narayanan, Vairavan [3 ]
Tan, Li Kuo [1 ]
Rahmat, Kartini [1 ]
Ramli, Norlisah Mohd [1 ]
机构：
[1] Univ Malaya, Fac Med, Dept Biomed Imaging, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Fac Med, Dept Rehabil Med, Kuala Lumpur, Malaysia
[3] Univ Malaya, Fac Med, Neurosurg Div Surg Dept, Kuala Lumpur, Malaysia
来源：
NEUROLOGY ASIA | 2024年 / 29卷 / 04期
关键词：
Mild traumatic brain injury; NODDI; DTI; cognitive impairment; WHITE-MATTER; MICROSTRUCTURE; DTI;
D O I：
10.54029/2024exe
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: Cognitive deficits in mild traumatic brain injury (mTBI) can persist over three months, and symptomatic patients may not be readily diagnosed. Although diffusion tensor imaging (DTI) can detect microstructural white matter tract (WMT) changes in mTBI, the underlying recovery process is not fully understood. We aimed to investigate WMT changes at 3 months post-mTBI between cognitively recovered (REC) and non-recovered (NREC) mTBI subjects using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Methods: Fifty-seven mTBI subjects were divided into REC (n=16) and NREC (n=41) groups. Ten healthy controls (HC) were recruited. assessed at baseline and three months before subjects were classified as REC and NREC. DTI and NODDI parameters of 50 ROIs corresponding to WMTs were compared between REC, NREC and HC. Results: NODDI detected more significant changes (p<0.05) in multiple ROIs than DTI. Lower Neurite Density Index (NDI) was demonstrated in REC versus NREC at multiple ROIs. Increased Orientation Dispersion Index (ODI) and decreased Isotropic Volume Fraction (ISOVF) were detected at several WMTs in both groups. Conclusion: Reduced NDI in the overall mTBI cohort suggests axonal degeneration post-trauma. We postulate that at three months' timeline, there is a combination of axonal degeneration and astrogliosis, which is more extensive in NREC than REC.
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页码：1141 / 1154
页数：14
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