Precision Medicine in Oncology: Personalized Approaches for Diagnosis, Treatment, and Prognosis

被引:0
作者
Smith, John [1 ]
Johnson, Sarah [2 ]
机构
[1] Univ Melbourne, Melbourne, Vic, Australia
[2] Univ Sydney, Sydney, NSW, Australia
来源
CINEFORUM | 2024年 / 65卷 / 03期
关键词
Precision Medicine; Oncology; Personalized; Diagnosis; Treatment; etc; CANCER;
D O I
暂无
中图分类号
J9 [电影、电视艺术]; I235 [电影、电视、广播剧];
学科分类号
摘要
Precision medicine has emerged as a transformative approach in oncology, offering personalized strategies for cancer diagnosis, treatment, and prognosis. This paper provides a comprehensive overview of precision medicine's role in oncology, focusing on genomic profiling, targeted therapies, immunotherapy, liquid biopsies, and personalized monitoring. By analyzing the genetic and molecular characteristics of individual tumors, precision medicine enables the identification of specific mutations and biomarkers that drive cancer progression. This knowledge facilitates the selection of targeted therapies tailored to each patient's unique tumor biology, improving treatment efficacy while minimizing adverse effects. Additionally, immunotherapy harnesses the body's immune system to target cancer cells, with biomarkers guiding patient selection and predicting treatment response. Liquid biopsies offer a non-invasive method for detecting circulating tumor DNA and monitoring treatment response over time.
引用
收藏
页码:168 / 171
页数:4
相关论文
共 10 条
  • [1] A New Initiative on Precision Medicine
    Collins, Francis S.
    Varmus, Harold
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (09) : 793 - 795
  • [2] First FDA Authorization for Next-Generation Sequencer
    Collins, Francis S.
    Hamburg, Margaret A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (25) : 2369 - 2371
  • [3] PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
    Le, D. T.
    Uram, J. N.
    Wang, H.
    Bartlett, B. R.
    Kemberling, H.
    Eyring, A. D.
    Skora, A. D.
    Luber, B. S.
    Azad, N. S.
    Laheru, D.
    Biedrzycki, B.
    Donehower, R. C.
    Zaheer, A.
    Fisher, G. A.
    Crocenzi, T. S.
    Lee, J. J.
    Duffy, S. M.
    Goldberg, R. M.
    de la Chapelle, A.
    Koshiji, M.
    Bhaijee, F.
    Huebner, T.
    Hruban, R. H.
    Wood, L. D.
    Cuka, N.
    Pardoll, D. M.
    Papadopoulos, N.
    Kinzler, K. W.
    Zhou, S.
    Cornish, T. C.
    Taube, J. M.
    Anders, R. A.
    Eshleman, J. R.
    Vogelstein, B.
    Diaz, L. A., Jr.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) : 2509 - 2520
  • [4] Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    Prahallad, Anirudh
    Sun, Chong
    Huang, Sidong
    Di Nicolantonio, Federica
    Salazar, Ramon
    Zecchin, Davide
    Beijersbergen, Roderick L.
    Bardelli, Alberto
    Bernards, Rene
    [J]. NATURE, 2012, 483 (7387) : 100 - U146
  • [5] Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial
    Rodon, J.
    Soria, J. C.
    Berger, R.
    Batist, G.
    Tsimberidou, A.
    Bresson, C.
    Lee, J. J.
    Rubin, E.
    Onn, A.
    Schilsky, R. L.
    Miller, W. H.
    Eggermont, A. M.
    Mendelsohn, J.
    Lazar, V.
    Kurzrock, R.
    [J]. ANNALS OF ONCOLOGY, 2015, 26 (08) : 1791 - 1798
  • [6] Implementing personalized cancer care
    Schilsky, Richard L.
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2014, 11 (07) : 432 - 438
  • [7] Tyrosine kinase gene rearrangements in epithelial malignancies
    Shaw, Alice T.
    Hsu, Peggy P.
    Awad, Mark M.
    Engelman, Jeffrey A.
    [J]. NATURE REVIEWS CANCER, 2013, 13 (11) : 772 - 787
  • [8] Integrating liquid biopsies into the management of cancer
    Siravegna, Giulia
    Marsoni, Silvia
    Siena, Salvatore
    Bardelli, Alberto
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2017, 14 (09) : 531 - 548
  • [9] Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
    Tie, Jeanne
    Wang, Yuxuan
    Tomasetti, Cristian
    Li, Lu
    Springer, Simeon
    Kinde, Isaac
    Silliman, Natalie
    Tacey, Mark
    Wong, Hui-Li
    Christie, Michael
    Kosmider, Suzanne
    Skinner, Iain
    Wong, Rachel
    Steel, Malcolm
    Tran, Ben
    Desai, Jayesh
    Jones, Ian
    Haydon, Andrew
    Hayes, Theresa
    Price, Tim J.
    Strausberg, Robert L.
    Diaz, Luis A., Jr.
    Papadopoulos, Nickolas
    Kinzler, Kenneth W.
    Vogelstein, Bert
    Gibbs, Peter
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (346)
  • [10] Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer
    Topalian, Suzanne L.
    Hodi, F. Stephen
    Brahmer, Julie R.
    Gettinger, Scott N.
    Smith, David C.
    McDermott, David F.
    Powderly, John D.
    Carvajal, Richard D.
    Sosman, Jeffrey A.
    Atkins, Michael B.
    Leming, Philip D.
    Spigel, David R.
    Antonia, Scott J.
    Horn, Leora
    Drake, Charles G.
    Pardoll, Drew M.
    Chen, Lieping
    Sharfman, William H.
    Anders, Robert A.
    Taube, Janis M.
    McMiller, Tracee L.
    Xu, Haiying
    Korman, Alan J.
    Jure-Kunkel, Maria
    Agrawal, Shruti
    McDonald, Daniel
    Kollia, Georgia D.
    Gupta, Ashok
    Wigginton, Jon M.
    Sznol, Mario
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) : 2443 - 2454