How to Predict Recurrence After Resection of Hepatocellular Carcinoma

被引：0

作者：

Petruch, Natalie ^{[1
,2
,3
]}

Bolm, Louisa ^{[1
,2
,3
]}

Nebbia, Martina ^{[1
,2
,4
]}

Arya, Shahrzad ^{[1
,2
,5
]}

Ventin, Marco ^{[1
,2
,5
]}

Qadan, Motaz ^{[1
,2
]}

Elias, Nahel ^{[1
,2
]}

Duhn, Jannis ^{[1
,2
,3
]}

Rades, Dirk ^{[1
,2
,6
]}

Dageforde, Leigh a. ^{[1
,2
]}

Tanabe, Kenneth T. ^{[1
,2
]}

Franses, Joseph ^{[1
,2
,7
]}

Deshpande, Vikram ^{[1
,2
,8
]}

Wellner, Ulrich F. ^{[1
,2
,3
]}

Keck, Tobias ^{[1
,2
,3
]}

Catalano, Onofrio ^{[1
,2
,9
]}

Ferrone, Cristina R. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Surg, Boston, MA USA

[2] Harvard Med Sch, Boston, MA USA

[3] Univ Med Ctr Schleswig Holstein, Dept Surg, Lubeck, Germany

[4] Humanitas Res Hosp, Dept Surg, Unit Pancreat Surg, Milan, Italy

[5] Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA USA

[6] Univ Lubeck, Dept Radiat Oncol, Lubeck, Germany

[7] Massachusetts Gen Hosp, Dept Med Oncol, Boston, MA USA

[8] Beth Israel Deaconess Med Ctr, Dept Pathol, New York, NY USA

[9] Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

来源：

ANTICANCER RESEARCH | 2025年 / 45卷 / 01期

关键词：

Hepatocellular carcinoma; surgcal resection; recurrence; prognostic score; LIVER-TRANSPLANTATION; PATTERNS;

D O I：

10.21873/anticanres.17404

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Predictors of recurrence following resection of hepatocellular carcinoma (HCC) are not fully established. This study investigated potential risk factors and prognostic scores for this situation. Patients and Methods: In 297 patients undergoing resection of HCC between 2000 and 2021, risk scores and potential additional risk factors for intrahepatic and extrahepatic recurrence were assessed. Results: Median overall survival was 48.4 months, median time to recurrence 25.1 months. The Alpha-Fetoprotein (AFP)-score differentiated between low and high-risk groups (21.8 vs. 8.3 months, p=0.001), as did the Risk Estimation of Tumor Recurrence After Transplant (RETREAT)-score (16 vs. 9 months, p=0.004) and the Clinical Risk Score (CRS) (14.9 vs. 3.9 months, p=0.002). Advanced T-stage, multiple lesions, and vessel infiltration were significantly associated with any type of recurrence, advanced T-stage, and multiple lesions with intrahepatic recurrence. Conclusion: Predictors of recurrence following resection of HCC were identified. Prognostic scores traditionally used for patients receiving liver transplantation (AFP-score, RETREAT-score, CRS) were predictive also of recurrence after resection of HCC.

引用

页码：189 / 199

页数：11

共 24 条

[1]

Amin MB, 2017, AJCC Cancer Staging Manual

[2] Expansion of Liver Transplantation Criteria for Hepatocellular Carcinoma from Milan to UCSF in Australia and New Zealand and Justification for Metroticket 2.0 [J].

Barreto, Savio G. ;

Strasser, Simone, I ;

McCaughan, Geoffrey W. ;

Fink, Michael A. ;

Jones, Robert ;

McCall, John ;

Munn, Stephen ;

Macdonald, Graeme A. ;

Hodgkinson, Peter ;

Jeffrey, Gary P. ;

Jaques, Bryon ;

Crawford, Michael ;

Brooke-Smith, Mark E. ;

Chen, John W. .

CANCERS, 2022, 14 (11)

[3]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[4]

BRODERS A C Sr, 1953, Tex State J Med, V49, P234

[5] Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial [J].

Bruix, Jordi ;

Takayama, Tadatoshi ;

Mazzaferro, Vincenzo ;

Chau, Gar-Yang ;

Yang, Jiamei ;

Kudo, Masatoshi ;

Cai, Jianqiang ;

Poon, Ronnie T. ;

Han, Kwang-Hyub ;

Tak, Won Young ;

Lee, Han Chu ;

Song, Tianqiang ;

Roayaie, Sasan ;

Bolondi, Luigi ;

Lee, Kwan Sik ;

Makuuchi, Masatoshi ;

Souza, Fabricio ;

Le Berre, Marie-Aude ;

Meinhardt, Gerold ;

Llovet, Josep M. .

LANCET ONCOLOGY, 2015, 16 (13) :1344-1354

[6] Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria [J].

Duvoux, Christophe ;

Roudot-Thoraval, Francoise ;

Decaens, Thomas ;

Pessione, Fabienne ;

Badran, Hanaa ;

Piardi, Tullio ;

Francoz, Claire ;

Compagnon, Philippe ;

Vanlemmens, Claire ;

Dumortier, Jerome ;

Dharancy, Sebastien ;

Gugenheim, Jean ;

Bernard, Pierre-Henri ;

Adam, Rene ;

Radenne, Sylvie ;

Muscari, Fabrice ;

Conti, Filomena ;

Hardwigsen, Jean ;

Pageaux, Georges-Philippe ;

Chazouilleres, Olivier ;

Salame, Ephrem ;

Hilleret, Marie-Noelle ;

Lebray, Pascal ;

Abergel, Armand ;

Debette-Gratien, Marilyne ;

Kluger, Michael D. ;

Mallat, Ariane ;

Azoulay, Daniel ;

Cherqui, Daniel .

GASTROENTEROLOGY, 2012, 143 (04) :986-+

[7] Predicting survival after liver transplantation in patients with hepatocellular carcinoma using the LiTES-HCC score [J].

Goldberg, David ;

Mantero, Alejandro ;

Newcomb, Craig ;

Delgado, Cindy ;

Forde, Kimberly A. ;

Kaplan, David E. ;

John, Binu ;

Nuchovich, Nadine ;

Dominguez, Barbara ;

Emanuel, Ezekiel ;

Reese, Peter P. .

JOURNAL OF HEPATOLOGY, 2021, 74 (06) :1398-1406

[8] Adjuvant therapy following curative treatments for hepatocellular carcinoma: current dilemmas and prospects [J].

Guo, Bin ;

Chen, Qian ;

Liu, Zhicheng ;

Chen, Xiaoping ;

Zhu, Peng .

FRONTIERS IN ONCOLOGY, 2023, 13

[9] The actual five-year survival rate of hepatocellular carcinoma patients after curative resection [J].

Lee, JG ;

Kang, CM ;

Park, JS ;

Kim, KS ;

Yoon, DS ;

Choi, JS ;

Lee, WJ ;

Kim, BR .

YONSEI MEDICAL JOURNAL, 2006, 47 (01) :105-112

[10] Predicting recurrence patterns after resection of hepatocellular cancer [J].

Lee, Ser Yee ;

Konstantinidis, Ioannis T. ;

Eaton, Anne A. ;

Goenen, Mithat ;

Kingham, T. Peter ;

D'Angelica, Michael I. ;

Allen, Peter J. ;

Fong, Yuman ;

DeMatteo, Ronald P. ;

Jarnagin, William R. .

HPB, 2014, 16 (10) :943-953

← 1 2 3 →