Macrolide-resistant Bordetella pertussis strain identified during an ongoing epidemic, Finland, January to October 2024

被引：2

作者：

Miettinen, Milja ^{[1
,2
,3
,4
]}

Barkoff, Alex-Mikael ^{[1
,4
]}

Nyqvist, Aino ^{[5
]}

Savolainen-Kopra, Carita ^{[5
]}

Antikainen, Jenni ^{[6
,7
]}

Mertsola, Jussi ^{[1
,4
]}

Ivaska, Lauri ^{[2
,3
,4
]}

He, Qiushui ^{[1
,4
]}

Milja, Miettinen

Alex-Mikael, Barkoff

Aino, Nyqvist

Carita, Savolainen-Kopra

Jenni, Antikainen

Jussi, Mertsola

Lauri, Ivaska

Qiushui, He

机构：

[1] Univ Turku, Inst Biomed, Finnish Reference Lab Diphther & Pertussis, Turku, Finland

[2] Turku Univ Hosp, Dept Paediat & Adolescent Med, Turku, Finland

[3] Univ Turku, Turku, Finland

[4] Univ Turku, InFLAMES Res Flagship Ctr, Turku, Finland

[5] Finnish Inst Hlth & Welf, Dept Publ Hlth, Helsinki, Finland

[6] Univ Helsinki, HUS Diagnost Ctr, Clin Microbiol, Bacteriol, Helsinki, Finland

[7] Helsinki Univ Hosp, Helsinki, Finland

来源：

EUROSURVEILLANCE | 2024年 / 29卷 / 49期

关键词：

PERTACTIN;

D O I：

10.2807/1560-7917.ES.2024.29.49.2400765

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since April 2024, a pertussis epidemic has been ongoing in Finland with 2,215 notified cases by end October. Of them, 30.1% (n = 667) were aged 10-14 years. Of the 462 Bordetella pertussis isolates characterised, one was macrolide-resistant (minimum inhibitory concentration (MIC) of erythromycin, azithromycin and clarithromycin > 256 mu g/mL). The resistant isolate was serotype FIM2, vaccine antigen pertactin-deficient and harboured ptxP 3 allele. The emergence of macrolideresistant B. pertussis in Europe is worrisome and its rapid identification is important.

引用

页数：6

共 18 条

[11]

Heinonen S, 2024, Working document 40/2024, whooping cough vaccines for pregnant people

[12] Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges [J].

Ivaska, Lauri ;

Barkoff, Alex-Mikael ;

Mertsola, Jussi ;

He, Qiushui .

ANTIBIOTICS-BASEL, 2022, 11 (11)

[13] Rapid detection of the recently emerged Bordetella pertussis strains with the ptxP3 pertussis toxin promoter allele by real-time PCR [J].

Kallonen, T. ;

Mertsola, J. ;

Mooi, F. R. ;

He, Q. .

CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (10) :E377-E379

[14] Antimicrobial susceptibility testing of Finnish Bordetella pertussis isolates collected during 2006-2017 [J].

Lonnqvist, Emilia ;

Barkoff, Alex-Mikael ;

Mertsola, Jussi ;

He, Qiushui .

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2018, 14 :12-16

[15] Rapid identification of Bordetella pertussis pertactin gene variants using LightCycler real-time polymerase chain reaction combined with melting curve analysis and gel electrophoresis [J].

Mäkinen, J ;

Viljanen, MK ;

Mertsola, J ;

Arvilommi, H ;

He, QS .

EMERGING INFECTIOUS DISEASES, 2001, 7 (06) :952-958

[16] Bordetella pertussis isolates in Finland after acellular vaccination: serotype change and biofilm formation [J].

Niinikoski, Vili ;

Barkoff, Alex-Mikael ;

Mertsola, Jussi ;

He, Qiushui .

CLINICAL MICROBIOLOGY AND INFECTION, 2024, 30 (05) :683e1-683e3

[17] Resurgence of Bordetella pertussis, , including one macrolide-resistant isolate, France, 2024 [J].

Rodrigues, Carla ;

Bouchez, Valerie ;

Soares, Anais ;

Trombert-Paolantoni, Sabine ;

El Belghiti, Fatima Ait ;

Cohen, Jeremie F. ;

Armatys, Nathalie ;

Landier, Annie ;

Blanchot, Thomas ;

Hervo, Marie ;

Toubiana, Julie ;

Brisse, Sylvain .

EUROSURVEILLANCE, 2024, 29 (31)

[18] Direct Detection of Erythromycin-Resistant Bordetella pertussis in Clinical Specimens by PCR [J].

Wang, Zengguo ;

Han, Ruijun ;

Liu, Ying ;

Du, Quanli ;

Liu, Jifeng ;

Ma, Chaofeng ;

Li, Hengxin ;

He, Qiushui ;

Yan, Yongping .

JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (11) :3418-3422

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