Macrolide-resistant Bordetella pertussis strain identified during an ongoing epidemic, Finland, January to October 2024

被引：2

作者：

Miettinen, Milja ^{[1
,2
,3
,4
]}

Barkoff, Alex-Mikael ^{[1
,4
]}

Nyqvist, Aino ^{[5
]}

Savolainen-Kopra, Carita ^{[5
]}

Antikainen, Jenni ^{[6
,7
]}

Mertsola, Jussi ^{[1
,4
]}

Ivaska, Lauri ^{[2
,3
,4
]}

He, Qiushui ^{[1
,4
]}

Milja, Miettinen

Alex-Mikael, Barkoff

Aino, Nyqvist

Carita, Savolainen-Kopra

Jenni, Antikainen

Jussi, Mertsola

Lauri, Ivaska

Qiushui, He

机构：

[1] Univ Turku, Inst Biomed, Finnish Reference Lab Diphther & Pertussis, Turku, Finland

[2] Turku Univ Hosp, Dept Paediat & Adolescent Med, Turku, Finland

[3] Univ Turku, Turku, Finland

[4] Univ Turku, InFLAMES Res Flagship Ctr, Turku, Finland

[5] Finnish Inst Hlth & Welf, Dept Publ Hlth, Helsinki, Finland

[6] Univ Helsinki, HUS Diagnost Ctr, Clin Microbiol, Bacteriol, Helsinki, Finland

[7] Helsinki Univ Hosp, Helsinki, Finland

来源：

EUROSURVEILLANCE | 2024年 / 29卷 / 49期

关键词：

PERTACTIN;

D O I：

10.2807/1560-7917.ES.2024.29.49.2400765

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since April 2024, a pertussis epidemic has been ongoing in Finland with 2,215 notified cases by end October. Of them, 30.1% (n = 667) were aged 10-14 years. Of the 462 Bordetella pertussis isolates characterised, one was macrolide-resistant (minimum inhibitory concentration (MIC) of erythromycin, azithromycin and clarithromycin > 256 mu g/mL). The resistant isolate was serotype FIM2, vaccine antigen pertactin-deficient and harboured ptxP 3 allele. The emergence of macrolideresistant B. pertussis in Europe is worrisome and its rapid identification is important.

引用

页数：6

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