KSCN-Mediated One-Pot Thiocyanation Tandem Cyclization of Enaminones: a Facile Access to 2-amino/imino Thiazolo Fused Chromone and Coumarin Frameworks

被引：1

作者：

Kumawat, Akshay ^{[1
]}

Mansuri, Sumbul ^{[1
]}

Galla, Mary Sravani ^{[1
]}

Shankaraiah, Nagula ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 44期

关键词：

One-pot reaction; Thiocyanation; KSCN; Fused heterocyclics; N-bromosuccinimide; Tandem reaction; S BOND FORMATION; DERIVATIVES; DESIGN; SCAFFOLD;

D O I：

10.1002/ejoc.202400690

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid metal-free approach describing one-pot thiocyanation of chromone and coumarin enabling tandem cyclization via potassium thiocyanate as a sulfur surrogate was unveiled. Interestingly, this enaminone-mediated protocol facilitated straightforward access to medicinally significant 2-amino/imino thiazolo fused chromone and coumarin frameworks. This methodology provided good atom-economy, remarkable functional group tolerance, and scalability. Alongside establishing a wide substrate scope, it also provided a feasible scalability up to gram scale.

引用

页数：6

共 27 条

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