Nitrogen doped carbon quantum dots (N-CQDs) synthesized by a microwave assisted hydrothermal method in combination with gold nanoparticles (AuNPs) as sensitive dual sensor for antibiotic meropenem detection

被引：0

作者：

Tran, Ngoc Bich ^{[1
]}

Nguyen, Quang Khanh ^{[1
,2
]}

Dang, Tran Minh Ngoc ^{[1
]}

Tran, Tien Dat ^{[1
]}

Nguyen, Tuan Minh ^{[1
]}

Nguyen, Thi Kim Thuong ^{[1
]}

Vu, Duy Tung ^{[1
]}

Pham, Bach ^{[1
]}

Nguyen, Thi Anh Huong ^{[1
]}

Pham, Thi Ngoc Mai ^{[1
]}

机构：

[1] Vietnam Natl Univ, VNU Univ Sci, Fac Chem, 19 Thanh Tong, Hanoi 11000, Vietnam

[2] Hanyang Univ, Coll Nat Sci, Dept Chem, Seoul 04763, South Korea

来源：

MICROCHEMICAL JOURNAL | 2025年 / 210卷

关键词：

Nitrogen doped carbon quantum dots; Gold nanoparticles; Dual-mode sensor; off/on" fluorescence; Meropenem antibiotic; PYROLYSIS; MEDIA; IONS; FRET;

D O I：

10.1016/j.microc.2025.112977

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, nitrogen doped carbon quantum dots (N-CQDs) were synthesized by a microwave assisted hydrothermal method which enhanced fluorescence. When combined with gold nanoparticles (AuNPs), N-CQDs exhibited a "turn-off/on" fluorescence response in the presence of the antibiotic meropenem. Remarkably, the NCQDs/AuNPs enabled both fluorescence and colorimetric detection. Colorimetric sensing relied on a visible color change of the AuNPs from red to blue, triggered by the addition of meropenem, while fluorescence sensing was based on fluorescence recovery. Quantification was achieved by monitoring the absorbance ratio changes at 670 nm and 530 nm for colorimetry and fluorescence intensity recovery for fluorometry, both as functions of meropenem concentration. This dual-mode detection system presents a cost-effective, and environmentally friendly platform for both straightforward visual detection and ultrahigh sensitive (LOD 1 ppb) quantification of meropenem across a wide range of concentrations from 8 to 850 nM. The fluorescence-based method was successfully applied to analyze meropenem in pharmaceutical samples and human plasma, showing high reliability when cross-validated against the conventional LC-MS/MS technique.

引用

页数：10

共 66 条

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