Biomedical Application of Enzymatically Crosslinked Injectable Hydrogels

被引:1
|
作者
Nam, Minho [1 ]
Lee, Jong Won [1 ]
Cha, Gi Doo [1 ]
机构
[1] Chung Ang Univ, Dept Syst Biotechnol, Anseong 17546, South Korea
基金
新加坡国家研究基金会;
关键词
injectable hydrogel; enzymatic crosslinking; biomedical application; HYALURONIC-ACID HYDROGEL; FORMED IN-SITU; GELATIN HYDROGEL; MICROBIAL TRANSGLUTAMINASE; TYRAMINE HYDROGELS; PREVENTION; STIFFNESS; DELIVERY; RELEASE; LINKING;
D O I
10.3390/gels10100640
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Hydrogels have garnered significant interest in the biomedical field owing to their tissue-like properties and capability to incorporate various fillers. Among these, injectable hydrogels have been highlighted for their unique advantages, especially their minimally invasive administration mode for implantable use. These injectable hydrogels can be utilized in their pristine forms or as composites by integrating them with therapeutic filler materials. Given their primary application in implantable platforms, enzymatically crosslinked injectable hydrogels have been actively explored due to their excellent biocompatibility and easily controllable mechanical properties for the desired use. This review introduces the crosslinking mechanisms of such hydrogels, focusing on those mediated by horseradish peroxidase (HRP), transglutaminase (TG), and tyrosinase. Furthermore, several parameters and their relationships with the intrinsic properties of hydrogels are investigated. Subsequently, the representative biomedical applications of enzymatically crosslinked-injectable hydrogels are presented, including those for wound healing, preventing post-operative adhesion (POA), and hemostasis. Furthermore, hydrogel composites containing filler materials, such as therapeutic cells, proteins, and drugs, are analyzed. In conclusion, we examine the scientific challenges and directions for future developments in the field of enzymatically crosslinked-injectable hydrogels, focusing on material selection, intrinsic properties, and filler integration.
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页数:20
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