Biomedical Application of Enzymatically Crosslinked Injectable Hydrogels

被引:1
|
作者
Nam, Minho [1 ]
Lee, Jong Won [1 ]
Cha, Gi Doo [1 ]
机构
[1] Chung Ang Univ, Dept Syst Biotechnol, Anseong 17546, South Korea
基金
新加坡国家研究基金会;
关键词
injectable hydrogel; enzymatic crosslinking; biomedical application; HYALURONIC-ACID HYDROGEL; FORMED IN-SITU; GELATIN HYDROGEL; MICROBIAL TRANSGLUTAMINASE; TYRAMINE HYDROGELS; PREVENTION; STIFFNESS; DELIVERY; RELEASE; LINKING;
D O I
10.3390/gels10100640
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Hydrogels have garnered significant interest in the biomedical field owing to their tissue-like properties and capability to incorporate various fillers. Among these, injectable hydrogels have been highlighted for their unique advantages, especially their minimally invasive administration mode for implantable use. These injectable hydrogels can be utilized in their pristine forms or as composites by integrating them with therapeutic filler materials. Given their primary application in implantable platforms, enzymatically crosslinked injectable hydrogels have been actively explored due to their excellent biocompatibility and easily controllable mechanical properties for the desired use. This review introduces the crosslinking mechanisms of such hydrogels, focusing on those mediated by horseradish peroxidase (HRP), transglutaminase (TG), and tyrosinase. Furthermore, several parameters and their relationships with the intrinsic properties of hydrogels are investigated. Subsequently, the representative biomedical applications of enzymatically crosslinked-injectable hydrogels are presented, including those for wound healing, preventing post-operative adhesion (POA), and hemostasis. Furthermore, hydrogel composites containing filler materials, such as therapeutic cells, proteins, and drugs, are analyzed. In conclusion, we examine the scientific challenges and directions for future developments in the field of enzymatically crosslinked-injectable hydrogels, focusing on material selection, intrinsic properties, and filler integration.
引用
收藏
页数:20
相关论文
共 50 条
  • [31] Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
    Li, Yulin
    Rodrigues, Joao
    Tomas, Helena
    CHEMICAL SOCIETY REVIEWS, 2012, 41 (06) : 2193 - 2221
  • [32] Nano-crosslinked dynamic hydrogels for biomedical applications
    Wang, Qinghe
    Zhang, Yan
    Ma, Yue
    Wang, Miao
    Pan, Guoqing
    MATERIALS TODAY BIO, 2023, 20
  • [33] Emerging Role of Injectable Dipeptide Hydrogels in Biomedical Applications
    Kulkarni, Neeraj
    Rao, Prajakta
    Jadhav, Govinda Shivaji
    Kulkarni, Bhakti
    Kanakavalli, Nagaraju
    Kirad, Shivani
    Salunke, Sujit
    Tanpure, Vrushali
    Sahu, Bichismita
    ACS OMEGA, 2023,
  • [34] Cartilage adhesive and mechanical properties of enzymatically crosslinked polysaccharide tyramine conjugate hydrogels
    Wang, R.
    Leber, N.
    Buhl, C.
    Verdonschot, N.
    Dijkstra, P. J.
    Karperien, M.
    POLYMERS FOR ADVANCED TECHNOLOGIES, 2014, 25 (05) : 568 - 574
  • [35] Enzymatically crosslinked gelatin-laminin hydrogels for applications in neuromuscular tissue engineering
    Besser, Rachel R.
    Bowles, Annie C.
    Alassaf, Ahmad
    Carbonero, Daniel
    Claure, Isabella
    Jones, Ellery
    Reda, Joseph
    Wubker, Laura
    Batchelor, Wyndham
    Ziebarth, Noel
    Silvera, Risset
    Khan, Aisha
    Maciel, Renata
    Saporta, Mario
    Agarwal, Ashutosh
    BIOMATERIALS SCIENCE, 2020, 8 (02) : 591 - 606
  • [36] An Injectable Enzymatically Crosslinked Carboxymethylated Pullulan/Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering
    Feng Chen
    Songrui Yu
    Bing Liu
    Yunzhou Ni
    Chunyang Yu
    Yue Su
    Xinyuan Zhu
    Xiaowei Yu
    Yongfeng Zhou
    Deyue Yan
    Scientific Reports, 6
  • [37] Application of injectable hydrogels in cancer immunotherapy
    Liu, Chutong
    Liao, Yingying
    Liu, Lei
    Xie, Luoyijun
    Liu, Junbo
    Zhang, Yumao
    Li, Yuzhen
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 11
  • [38] An Injectable Enzymatically Crosslinked Carboxymethylated Pullulan/Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering
    Chen, Feng
    Yu, Songrui
    Liu, Bing
    Ni, Yunzhou
    Yu, Chunyang
    Su, Yue
    Zhu, Xinyuan
    Yu, Xiaowei
    Zhou, Yongfeng
    Yan, Deyue
    SCIENTIFIC REPORTS, 2016, 6
  • [39] Characterization and Optimization of Injectable In Situ Crosslinked Chitosan-Genipin Hydrogels
    Priddy-Arrington, Tyler R.
    Edwards, Reagan E.
    Colley, Claire E.
    Nguyen, Marissa M.
    Hamilton-Adaire, Tess
    Caldorera-Moore, Mary E.
    MACROMOLECULAR BIOSCIENCE, 2023, 23 (06)
  • [40] Enzymatically crosslinked carboxymethyl-chitosan/gelatin/nano-hydroxyapatite injectable gels for in situ bone tissue engineering application
    Mishra, Debasish
    Bhunia, Bibhas
    Banerjee, Indranil
    Datta, Pallab
    Dhara, Santanu
    Maiti, Tapas K.
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2011, 31 (07): : 1295 - 1304