Acid-Promoted Phosphorylation of Ynones for the Synthesis of Phosphoryl Enones

被引：0

作者：

Wei, Xiao-Hong ^{[1
]}

Xue, Ya-Wen ^{[1
]}

Jiang, Xiu-Mei ^{[1
]}

Quan, Gang-Gui ^{[1
]}

Ye, Jia-Qiang ^{[1
]}

Guo, Xu ^{[1
]}

Liu, Xuan ^{[1
]}

机构：

[1] Northwest Minzu Univ, Coll Chem Engn, Key Lab Util Environm Friendly Composite Mat & Bio, Key Lab Environm Friendly Composite Mat,State Ethn, Lanzhou 730030, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 05期

关键词：

ALKYNYL KETONES; METAL; ACCESS; FUNCTIONALIZATION; SPIROCYCLIZATION; CYANOSILYLATION; CYCLIZATION; ACTIVATION; CLEAVAGE;

D O I：

10.1021/acs.orglett.4c04531

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient phospha-aldol/Meyer-Schuster rearrangement cascade reaction between propargylic aldehydes and phosphine oxides has been developed in which various phosphoryl enones were obtained in moderate to excellent yields. A comprehensive series of mechanistic experiments, including the identification of key intermediates and the application of 18O isotope labeling, has confirmed that this cascade reaction proceeds through a phospha-aldol followed by Meyer-Schuster rearrangement cascade reaction.

引用

页码：1124 / 1129

页数：6

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