Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats

被引:1
作者
Ortelli, Olivia A. [1 ]
Weiner, Jeffrey L. [1 ]
机构
[1] Wake Forest Univ, Sch Med, Dept Translat Neurosci, Winston Salem, NC 27109 USA
来源
ADDICTION NEUROSCIENCE | 2025年 / 14卷
基金
美国国家卫生研究院;
关键词
Choice; Ethanol; Self-administration; Sex differences; Sucrose; ALCOHOL-USE DISORDERS; CONSUMMATORY BEHAVIORS; CONTINGENCY MANAGEMENT; NUCLEUS-ACCUMBENS; SEX-DIFFERENCES; PREFERRING P; SEEKING; DRINKING; YOHIMBINE; CONSUMPTION;
D O I
10.1016/j.addicn.2025.100196
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Investigating how environmental factors, such as the availability of non-ethanol alternative reinforcers, influences ethanol self-administration is critical for understanding the pathology of alcohol use disorder (AUD). Here we established the first operant choice paradigm that leverages the strengths of the sipper tube selfadministration model to investigate how concurrent access to sucrose altered ethanol self-administration in male and female Long Evans rats. Choice behavior was examined using two distinct paradigms, including a novel adaptation of the response requirement paradigm. Under both a fixed-ratio or response requirement paradigm, we observed that concurrent availability of an alternative reinforcer significantly reduced appetitive and consummatory ethanol drinking-related behaviors. Furthermore, we assessed the sensitivity of the response requirement choice paradigm by administering the pharmacological stressor yohimbine and by altering the taste of the ethanol solution. Yohimbine administration non-selectively increased ethanol and sucrose intake, but not seeking, while taste adulteration decreased ethanol seeking and intake. These experiments demonstrate the utility of two concurrent choice paradigms that can more accurately capture AUD-like phenotypes, such as ethanol-directed choice in the face of alternative reinforcers. Future studies should investigate how models of vulnerability and dependence alter ethanol choice behavior under these paradigms.
引用
收藏
页数:12
相关论文
共 66 条
[21]   Ethanol- and sucrose-reinforced appetitive and consummatory responding in HAD1, HAD2, and P rats [J].
Czachowski, CL ;
Samson, HH .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2002, 26 (11) :1653-1661
[22]   Behavioral and Neurotransmitter Specific Roles for the Ventral Tegmental Area in Reinforcer-Seeking and Intake [J].
Czachowski, Cristine L. ;
DeLory, Michael J. ;
Pope, Jason D. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2012, 36 (10) :1659-1668
[23]   Development of a Nonhuman Primate Model of Resistance to Punishment of Ethanol Choice [J].
Czoty, Paul W. ;
Stinson, Benjamin T. .
FASEB JOURNAL, 2022, 36
[24]   Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation [J].
Deal, Alex L. ;
Bass, Caroline E. ;
Grinevich, Valentina P. ;
Delbono, Osvaldo ;
Bonin, Keith D. ;
Weiner, Jeff L. ;
Budygin, Evgeny A. .
NEUROSCIENCE, 2020, 443 :84-92
[25]   Using Contingency Management Procedures to Reduce At-Risk Drinking in Heavy Drinkers [J].
Dougherty, Donald M. ;
Lake, Sarah L. ;
Hill-Kapturczak, Nathalie ;
Liang, Yuanyuan ;
Karns, Tara E. ;
Mullen, Jillian ;
Roache, John D. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2015, 39 (04) :743-751
[26]   Shortening time for access to alcohol drives up front-loading behavior, bringing consumption in male rats to the level of females [J].
Flores-Bonilla, Annabelle ;
De Oliveira, Barbara ;
Silva-Gotay, Andrea ;
Lucier, Kyle W. ;
Richardson, Heather N. .
BIOLOGY OF SEX DIFFERENCES, 2021, 12 (01)
[27]   Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task [J].
Fukushima, Shou ;
Kuga, Hironori ;
Oribe, Naoya ;
Mutou, Takeo ;
Yuzuriha, Takefumi ;
Ozawa, Hiroki ;
Ueno, Takefumi .
PLOS ONE, 2020, 15 (07)
[28]   Sex differences in sucrose reinforcement in Long-Evans rats [J].
Grimm, Jeffrey W. ;
North, Katherine ;
Hopkins, Madeleine ;
Jiganti, Kyle ;
McCoy, Alex ;
Sulc, Josef ;
MacDougall, Derek ;
Sauter, Frances .
BIOLOGY OF SEX DIFFERENCES, 2022, 13 (01)
[29]   Noradrenergic targets for the treatment of alcohol use disorder [J].
Haass-Koffler, Carolina L. ;
Swift, Robert M. ;
Leggio, Lorenzo .
PSYCHOPHARMACOLOGY, 2018, 235 (06) :1625-1634
[30]  
Halekoh U, 2014, J STAT SOFTW, V59, P1