Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair

被引：0
|
作者：
Khodyreva, Svetlana N. [1 ]
Dyrkheeva, Nadezhda S. [1 ,2 ]
Lavrik, Olga I. [1 ,2 ,3 ]
机构：
[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, 8 Akad Lavrentyeva pr, Novosibirsk 630090, Russia
[2] Novosibirsk State Univ, Fac Nat Sci, 2 Pirogova Str, Novosibirsk 630090, Russia
[3] Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, 44 Thorez Pr, St Petersburg 194223, Russia
来源：
BIOMEDICINES | 2024年 / 12卷 / 12期
关键词：
alpha synuclein; amyloid beta; base excision repair; C9orf72; direct DNA repair; FUS; homologous recombination; huntingtin; liquid-liquid phase separation; mismatch repair; neurodegenerative disease; nonhomologous end joining; NONO; poly(ADP-ribose) polymerase 1; SFPQ; tau protein; TDP-43; BASE EXCISION-REPAIR; DOUBLE-STRAND BREAKS; TRANSCRIPTION-COUPLED REPAIR; POLYMERASE-BETA; DAMAGE RESPONSE; MISMATCH REPAIR; LYASE ACTIVITY; HUMAN-CELLS; MECHANISM; PATHWAY;
D O I：
10.3390/biomedicines12122808
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nervous system is susceptible to DNA damage and DNA repair defects, and if DNA damage is not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. The overall picture of what is known about DNA repair mechanisms in the nervous system is still unclear. The current challenge is to use the accumulated knowledge of basic science on DNA repair to improve the treatment of neurodegenerative disorders. In this review, we summarize the current understanding of the function of DNA damage repair, in particular, the base excision repair and double-strand break repair pathways as being the most important in nervous system cells. We summarize recent data on the proteins involved in DNA repair associated with neurodegenerative diseases, with particular emphasis on PARP1 and ND-associated proteins, which are involved in DNA repair and have the ability to undergo liquid-liquid phase separation.
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页数：34
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