Clinicopathological Features of Methotrexate-associated Lymphoproliferative Disorders in the Gastrointestinal Tract

被引：0
|
作者：
Edagawa, Takeya [1 ]
Iwagami, Hiroyoshi [1 ]
Akamatsu, Takuji [1 ]
Nakano, Shogo [1 ]
Wakita, Midori [1 ]
Konishi, Takafumi [1 ]
Nakatani, Yasuki [1 ]
Uenoyama, Yoshito [1 ]
Yamashita, Yukitaka [1 ]
机构：
[1] Japanese Red Cross Wakayama Med Ctr, Dept Gastroenterol & Hepatol, Wakayama, Japan
来源：
INTERNAL MEDICINE | 2025年 / 64卷 / 05期
关键词：
methotrexate; rheumatoid arthritis; lymphoproliferative disorder; gastrointestinal tract; LYMPHOMA;
D O I：
10.2169/internalmedicine.3719-24
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Methotrexate may cause methotrexate-associated lymphoproliferative disorder (MTX-LPD); however, this disease is uncommon in the gastrointestinal tract. We examined six patients with MTX-LPD in the gastrointestinal tract at our hospital. All of the lesions were ulcerative. Four cases regressed spontaneously, all of which were positive for Epstein-Barr virus-encoded small RNA by in situ hybridization. Two patients who did not regress were negative for Epstein-Barr virus RNA, one of whom received chemotherapy, and one underwent surgery. The prognosis of this disease is considered to be good. MTX-LPD should considered when ulcerative lesions are observed during endoscopy in patients receiving MTX.
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收藏
页码：687 / 693
页数：7
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