Use of Biosimilars to Infliximab During Pregnancy in Women With Inflammatory Bowel Disease: Results From the Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes Study

被引：0

作者：

Long, Millie D. ^{[1
]}

Kane, Sunanda ^{[2
]}

Beaulieu, Dawn ^{[3
]}

Abraham, Bincy ^{[4
]}

Zhang, Xian ^{[1
]}

Mahadevan, Uma ^{[5
]}

机构：

[1] Univ North Carolina, Chapel Hill, NC 27599 USA

[2] Mayo Clin, Rochester, MN USA

[3] Vanderbilt Univ, Nashville, TN USA

[4] Houston Methodist, Houston, TX USA

[5] Univ Calif San Francisco, San Francisco, CA USA

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2024年 / 15卷 / 12期

关键词：

inflammatory bowel disease; Crohn's disease; ulcerative colitis; pregnancy; biosimilar;

D O I：

10.14309/ctg.0000000000000795

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION: We aimed to compare pregnancy outcomes of women with inflammatory bowel disease using biosimilar vs originator infliximab (IFX). METHODS: In a prospective cohort of pregnant women with inflammatory bowel disease, we collected characteristics, medications, pregnancy outcomes, and developmental milestones. We compared outcomes by IFX biosimilar or originator use via bivariate statistics. RESULTS: A total of 100 pregnant women on originator IFX and 20 on biosimilar IFX were included. There were no differences in pregnancy complications between groups (48% vs 35%, P = 0.29). Infant developmental milestones were comparable at 12 months. DISCUSSION: Biosimilar IFX is not associated with adverse pregnancy or infant outcomes.

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