Unlocking ocular biomarkers for early detection of Alzheimer's disease

被引:1
作者
Dave, Nikhil [1 ]
Lee, Melissa [2 ]
Pavlou, Hania [3 ]
Im, Owen [3 ]
Goh, Kim [3 ]
Ulin, Sam [3 ]
Malzbender, Kristina [1 ]
Shobin, Eli [2 ]
Sukumar, Aishwarya [1 ]
机构
[1] Gates Ventures, 4110 Carillon Point, Kirkland, WA 98033 USA
[2] Alzheimers Drug Discovery Fdn, 57 West 57th St,Suite 904, New York, NY 10019 USA
[3] ClearView HealthCare Partners, Newton, MA USA
关键词
Alzheimer's disease; hyperspectral imaging; non-invasive screening; ocular biomarkers; ocular screening; optical coherence tomography; OPTICAL COHERENCE TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; FIBER LAYER THICKNESS; FUNCTIONAL RETINAL IMPAIRMENT; AMYLOID-BETA PLAQUES; PARKINSONS-DISEASE; ABNORMALITIES; DEMENTIA; PET;
D O I
10.1002/alz.14567
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent evidence suggests that ocular testing holds promise as a non-invasive and cost-effective method for the early detection of Alzheimer's disease (AD). After interviews with neurologists, optometrists, primary care physicians, and ophthalmologists, the potential for ocular biomarker testing to become a standard clinical practice in the future was assessed. Ocular tests offer a non-invasive alternative to blood-based testing, capturing a substantial niche of approximate to 4 to 8 million individuals in the United States during routine eye exams. Technical requirements for broad adoption include high accuracy comparable to blood-based tests and 510(k) clearance. Ocular biomarker technology must meet the practical requirements of optometrists and ophthalmologists, including ease of implementation, automation, and a clear path to profitability. A sufficient body of evidence to support guideline inclusion, reimbursement, and clinical actionability will facilitate the adoption. As the field evolves, advances such as earlier detection of preclinical AD may further expand the role of ocular testing.
引用
收藏
页数:9
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