Arachidonic acid in aging: New roles for old players

被引：9

作者：

Qian, Chen ^{[1
]}

Wang, Qing ^{[1
]}

Qiao, Yusen ^{[1
]}

Xu, Ze ^{[2
]}

Zhang, Linlin ^{[2
]}

Xiao, Haixiang ^{[1
]}

Lin, Zhixiang ^{[1
]}

Wu, Mingzhou ^{[1
]}

Xia, Wenyu ^{[1
]}

Yang, Huilin ^{[1
]}

Bai, Jiaxiang ^{[2
]}

Geng, Dechun ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Dept Orthoped, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China

[2] Univ Sci & Technol China, USTC, Affiliated Hosp 1, Dept Orthoped,Div Life Sci & Med, 17 Lujiang Rd, Hefei 230031, Anhui, Peoples R China

来源：

JOURNAL OF ADVANCED RESEARCH | 2025年 / 70卷

基金：

中国国家自然科学基金;

关键词：

Aging; Aging diseases; Arachidonic acid; Therapeutic strategies; POLYUNSATURATED FATTY-ACIDS; NF-KAPPA-B; AGE-RELATED-CHANGES; LEUKOCYTE TELOMERE LENGTH; EPITHELIAL-MESENCHYMAL TRANSITION; MESSENGER-RNA LEVELS; QUALITY-OF-LIFE; GROWTH-FACTOR-I; PROSTAGLANDIN E-2; DOCOSAHEXAENOIC ACID;

D O I：

10.1016/j.jare.2024.05.003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Arachidonic acid (AA), one of the most ubiquitous polyunsaturated fatty acids (PUFAs), provides fluidity to mammalian cell membranes. It is derived from linoleic acid (LA) and can be transformed into various bioactive metabolites, including prostaglandins (PGs), thromboxanes (TXs), lipoxins (LXs), hydroxy-eicosatetraenoic acids (HETEs), leukotrienes (LTs), and epoxyeicosatrienoic acids (EETs), by different pathways. All these processes are involved in AA metabolism. Currently, in the context of an increasingly visible aging world population, several scholars have revealed the essential role of AA metabolism in osteoporosis, chronic obstructive pulmonary disease, and many other aging diseases. Aim of Review: Although there are some reviews describing the role of AA in some specific diseases, there seems to be no or little information on the role of AA metabolism in aging tissues or organs. This review scrutinizes and highlights the role of AA metabolism in aging and provides a new idea for strategies for treating aging-related diseases. Key Scientific Concepts of Review: As a member of lipid metabolism, AA metabolism regulates the important lipids that interfere with the aging in several ways. We present a comprehensive review of the role of AA metabolism in aging, with the aim of relieving the extreme suffering of families and the heavy economic burden on society caused by age-related diseases. We also collected and summarized data on anti- aging therapies associated with AA metabolism, with the expectation of identifying a novel and efficient way to protect against aging. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：79 / 101

页数：23