The latest developments of near-infrared fluorescent probes from NIR-I to NIR-II for bioimaging

被引：3

作者：

Kuronuma, Yuzuka ^{[1
]}

Watanabe, Ryuji ^{[1
]}

Hiruta, Yuki ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, 3-14-1 Hiyoshi, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

ANALYTICAL SCIENCES | 2025年 / 41卷 / 06期

基金：

日本学术振兴会;

关键词：

Near-infrared; NIR-II; Fluorescent probe; Bioimaging; Cyanine; Rhodamine; RATIONAL DESIGN; GENERAL-METHOD; LIVE-CELL; FAR-RED; DYES; RHODAMINE; VIVO; NM; FLUOROPHORES; WAVELENGTH;

D O I：

10.1007/s44211-025-00735-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Near-infrared I (NIR-I: 650-950 nm) fluorescence imaging is a powerful tool for deep-tissue biological imaging, addressing the limitations of photon penetration depth in the visible-light region. Over the past decade, NIR imaging has extended to the near-infrared II (NIR-II: 1000-1700 nm) region, offering high-resolution and low background imaging by suppressing light scattering, and autofluorescence of tissues. Near-infrared fluorescent probes from NIR-I to NIR-II, with diverse functionalities, are increasingly utilized across biological fields to meet various detection needs and to explore physiological events in real time and spatial dimensions. This review discusses recent advancements in small-molecule NIR fluorescent dyes and probes, particularly those based on cyanine and rhodamine scaffolds, highlighting examples of their applications in bioimaging.

引用

页码：737 / 757

页数：21

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