Copper-Catalyzed Cross-Coupling of Bicyclobutanes with Triftosylhydrazone Leading to Skipped Dienes

被引：0

作者：

Zhang, Xiaolong ^{[1
]}

Tian, Tian ^{[1
]}

Liao, Peiqiu ^{[1
]}

Liu, Zhaohong ^{[1
]}

Murali, Karunanidhi ^{[1
]}

Bi, Xihe ^{[1
,2
]}

机构：

[1] Northeast Normal Univ, Dept Chem, Changchun 130024, Peoples R China

[2] Nankai Univ, State Key Lab Elemento Organ Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 10期

基金：

中国国家自然科学基金;

关键词：

BENZYLATION; STRAIN;

D O I：

10.1021/acs.orglett.4c04519

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report a protocol for the synthesis of skipped dienes through the cross-coupling of bicyclo[1.1.0]butanes with trifluoromethyl triftosylhydrazones. The reaction is run using TpBr3Cu(NCMe) as a catalyst to give access to a library of trifluoromethylated skipped dienes (32 examples, <= 98% yield) with excellent E/Z selectivity under mild and operationally safe conditions. The presented methods proved to be compatible with various functionalized bicyclo[1.1.0]butanes and triftosylhydrazones.

引用

页码：2300 / 2304

页数：5

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