TB-vaccines: Current status & challenges

被引：0
|
作者：
Sachdeva, Kuldeep Singh [1 ]
Chadha, Vineet K. [1 ]
机构：
[1] Natl TB Inst, Epidemiol & Res Div, Bengaluru, Karnataka, India
来源：
INDIAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 160卷 / 3-4期
关键词：
Key words Adult vaccination; BCG; challenges; newer approaches; newer vaccines; pipeline; tuberculosis; MYCOBACTERIUM-TUBERCULOSIS; HEALTHY-ADULTS; DOUBLE-BLIND; VACCINATION; PREVENTION; IMMUNOGENICITY; METAANALYSIS; PROTECTION; INFECTION; MACAQUES;
D O I：
10.25259/IJMR_1478_2024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tuberculosis continues to be among the leading causes of morbidity as well as mortality. It is appreciated that our aim of eliminating TB in the foreseeable future will not be realized until we have a new vaccine with significant efficacy among diverse populations and all age-groups. Although impressive strides have been made in more refined development of new TB vaccines based on learnings from past experiences, the substitute or a booster vaccine for the BCG vaccine is not available yet. This article puts in perspective the recent efforts in re-positioning BCG, development of newer vaccines based on novel approaches, the current TB vaccine pipeline, yet unmet challenges in vaccine development, exploring newer ideas in vaccine development and what the future holds.
引用
收藏
页码：338 / 345
页数：8
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