Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors as Potential Treatment for Several Inflammatory and Neurodegenerative Diseases

被引：0
|
作者：
Abdel-Magid, Ahmed F. [1 ]
机构：
[1] PI Hlth Sci, Chelsea, AL 35043 USA
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2025年 / 16卷 / 02期
关键词：
D O I：
10.1021/acsmedchemlett.5c00026
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The invention in this patent application relates to 2-amino-[1,2,4]triazolo[1,5-a]pyridin derivatives represented generally herein as formula 1. These compounds have activities as receptor-interacting protein kinase 1 (RIPK1) inhibitors and may potentially provide treatment and/or prophylaxis of inflammatory and neurodegenerative diseases associated with aberrant RIPK1 activity such as ulcerative colitis, Crohn's disease, psoriasis, NASH, heart failure, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Alzheimer's disease.
引用
收藏
页码：204 / 206
页数：3
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