Probe - Integrated electrochemical sensing platform for detection of trace levels of Dapoxetine hydrochloride drug residue in water and drug formulations

被引:0
作者
Alwael, H. [1 ]
Asiri, N. A. [1 ,2 ]
Alhogbi, B. G. [1 ]
Alharthi, A. S. [1 ,3 ]
Bahaidarah, E. A. [1 ]
Abduljabbar, T. N. [1 ]
Baamer, D. F. [1 ]
Madkour, M. [4 ]
Zainy, F. A. [2 ]
El-Shahawi, M. S. [1 ,5 ]
机构
[1] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21589, Saudi Arabia
[2] Univ Jeddah, Coll Sci, Dept Chem, Jeddah, Saudi Arabia
[3] Umm AL Qura Univ, Fac Appl Sci, Dept Chem, Mecca, Saudi Arabia
[4] King Abdulaziz Univ, Fac Environm Sci, Dept Environm, Jeddah, Saudi Arabia
[5] Damietta Univ, Fac Sci, Dept Chem, New Damietta, Damietta, Egypt
关键词
Dapoxetine hydrochloride formulations; Drug residues; Stripping voltammetry; Environmental water samples; PREMATURE EJACULATION; PHARMACEUTICALS; QUANTIFICATION; ENVIRONMENT; SAFETY;
D O I
10.1016/j.elecom.2025.107875
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
The extensive use and misuse of selective serotonin reuptake inhibitors (SSRIs) in drug formulations has resulted in their accumulation in food sources and environment, posing noteworthy threats to human health and the global economy. Dapoxetine hydrochloride (DPH) is one of the recent oral drugs frequently misused for the treatment of male sexual dysfunction of premature ejaculation and has lately international attention. Hence, the current study reports a simple and low cost electrochemical probe based on glassy carbon electrode (GCE) combining adsorptive square wave - anodic stripping voltammeter (Ads SW-ASV) for detection of DPH in aqueous solution at pH 3. The proposed probe displayed limits of detection (LOD) and quantification (LOQ) of 5.0 x 10- 7 and 1.56 x 10-6 M, respectively, with a wide linear dynamic range (LDR) of 1.0 x 10- 6-1.0 x 10-4 M of DPH. The sensor also revealed remarkable reproducibility, stability, and resistance towards interference. The probe also has favorable LOD and good LDR compared to the recent reported assays for DPH detection. The probe was applied for detection of DPH in its drug formulations and its residues in water samples with acceptable recoveries (98.5 +/- 0.014-104 +/- 0.016 %) with favorable repeatability and reproducibility. The experimental Student texp test (n = 5) was lower than tabulated t value t (2.78) at 95 % confidence (n = 5) demonstrating the reliability of the probe towards DPH detection in water and signifying the potential practices for DPH detection in complex matrices. Thus, the probe revealed good performance making it a talented candidate for practical detection of DPH. Interference of some frequently found components in drug residues in water and long-term stability of the probe was also assigned. The probe is simple, robust, and able to detect DPH in complex matrix with high recoveries.
引用
收藏
页数:10
相关论文
共 59 条
[1]   One -pot micellar augmented native fluorescence for facile fluorimetric assay of dapoxetine hydrochloride in biological plasma and tablets [J].
Abu-hassan, Ahmed A. ;
Ali, Ramadan ;
Derayea, Sayed M. .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2020, 239
[2]   Hypersensitive electrochemical sensor based on thermally annealed gold-silver alloy nanoporous matrices for the simultaneous determination of sulfathiazole and sulfamethoxazole residues in food samples [J].
Adane, Wondimeneh Dubale ;
Chandravanshi, Bhagwan Singh ;
Tessema, Merid .
FOOD CHEMISTRY, 2024, 457
[3]   A cutting-edge electrochemical sensing platform for the simultaneous determination of the residues of antimicrobial drugs, rifampicin and norfloxacin, in water samples [J].
Adane, Wondimeneh Dubale ;
Chandravanshi, Bhagwan Singh ;
Getachew, Negash ;
Tessema, Merid .
ANALYTICA CHIMICA ACTA, 2024, 1312
[4]   A novel electrochemical sensor for the detection of metronidazole residues in food samples [J].
Adane W.D. ;
Chandravanshi B.S. ;
Tessema M. .
Chemosphere, 2024, 359
[5]   Highly sensitive and selective electrochemical sensor for the simultaneous determination of tinidazole and chloramphenicol in food samples (egg, honey and milk) [J].
Adane, Wondimeneh Dubale ;
Chandravanshi, Bhagwan Singh ;
Tessema, Merid .
SENSORS AND ACTUATORS B-CHEMICAL, 2023, 390
[6]   A simple, ultrasensitive and cost-effective electrochemical sensor for the determination of ciprofloxacin in various types of samples [J].
Adane, Wondimeneh Dubale ;
Chandravanshi, Bhagwan Singh ;
Tessema, Merid .
SENSING AND BIO-SENSING RESEARCH, 2023, 39
[7]  
Affas S., 2019, Research J. Pharm. Technol., V12, P5193, DOI [10.5958/0974-360X.2019.00899.0, DOI 10.5958/0974-360X.2019.00899.0]
[8]   Recent advances in dispersive liquid-liquid microextraction for pesticide analysis [J].
Ahmad, W. ;
Al-Sibaai, A. A. ;
Bashammakh, A. S. ;
Alwael, H. ;
El-Shahawi, M. S. .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2015, 72 :181-192
[9]   Validated Capillary Zone Electrophoretic Determination of Avanafil and Dapoxetine Hydrochloride in their Pure form and Pharmaceutical Preparation [J].
Ali, Mohamed B. ;
Talaat, Wael ;
Omran, Gamal A. ;
Hendawy, Hassan A. M. ;
Morshedy, Samir .
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2021, 33 (46B) :446-459
[10]   Probe -integrated electrochemical sensing platform for measuring trace levels of parathion pesticides residues in water using Au- nanoparticles anchored Nafion nano composite modified glassy carbon electrode [J].
Alwael, H. ;
Al-Sedran, S. H. ;
Oubaha, M. ;
Asiri, N. A. A. ;
Bashammakh, A. S. ;
Alharthy, A. S. ;
Albassami, N. A. ;
Abduljabbar, T. N. ;
Mohammed, G. I. ;
Nassef, H. M. ;
Bahaidarah, E. A. ;
Alhogbi, B. G. ;
El-Shahawi, M. S. .
JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2023, 124