Sequence Notes: Characterization of Two Novel HIV-1 Unique Recombinant Forms (CRF01_AE/B) in Hebei Province

被引:0
作者
Zhang, Zhen [1 ]
Zhang, Yuchen [1 ]
Meng, Juan [1 ]
Fan, Weiguang [2 ]
Jia, Jianru [1 ]
Chen, Sisi [2 ]
Shi, Haoxi [2 ]
机构
[1] Peoples Hosp Baoding, Infect Div, Baoding, Peoples R China
[2] Peoples Hosp Baoding, Clin Lab, 608 Dongfeng East Rd, Baoding 071000, Hebei, Peoples R China
关键词
HIV-1; circulating recombinant form; unique recombinant form; homosexual; heterosexual;
D O I
10.1089/aid.2024.0122
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) of human immunodeficiency virus type-1 (HIV-1) have been discovered in populations with multiple circulating HIV-1 genotypes. In this study, we report two novel URFs derived from two HIV-1-positive individuals in Hebei, China, who were infected through homosexual (BDD142) and heterosexual (BDD154) contact. Phylogenetic and recombinant analyses of the two NFLG revealed that they are second-generation recombinant strains originating from the CRF01_AE cluster 4/B and CRF01_AE cluster 5/B strains. The BDD142 viral genome consists of a subtype B fragment inserted into a CRF01_AE backbone, whereas the BDD154 virus genome consists of two subtype B fragments inserted into a CRF01_AE backbone. Prompt monitoring of molecular epidemiological shifts of HIV-1 within sexually transmitted populations and enhanced behavioral interventions targeting this group are imperative to mitigate the spread of HIV-1 effectively.
引用
收藏
页码:279 / 284
页数:6
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