Multifunctional alumina scaffolds with enhanced bioactivity and antimicrobial properties for bone tissue engineering

被引：0
作者：
Santo, Daniela [1 ]
Rodarte, Mikhael [2 ]
Andreto, Crislayne [2 ]
Cavaleiro, Diogo [1 ]
Carvalho, Isabel [3 ,4 ]
Balestra, Roseli [2 ]
Carvalho, Sandra [1 ,5 ]
机构：
[1] Univ Coimbra, Dept Mech Engn, CEMMPRE, ARISE, P-3030788 Coimbra, Portugal
[2] Univ Sao Joao Rei, Postgrad Program Mech Engn, PPMEC, BR-306307352 Sao Joao Del Rei, Brazil
[3] Univ Minho, Ctr Biol Engn, Lab Invest Biofilmes Rosario Oliveira, CEB, Campus Gualtar, P-4710057 Braga, Portugal
[4] LABBELS Associate Lab, Guimaraes, Portugal
[5] IPN LED & MAT Inst Pedro Nunes, Lab Ensaios Desgaste & Mat, Rua Pedro Nunes, P-3030199 Coimbra, Portugal
来源：
CERAMICS INTERNATIONAL | 2025年 / 51卷 / 05期
关键词：
Alumina scaffolds; Magnetron sputtering; Osseointegration; Antimicrobial coating; THIN-FILMS; HYDROXYAPATITE; SURFACE; CERAMICS;
D O I：
10.1016/j.ceramint.2024.12.059
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Inert ceramic implants suffer from significant complications such as lack of osseointegration, biofilm formation, and infections, necessitating the development of novel materials with both osteogenic and antibacterial properties to prevent implant failure. In this study, we aimed to multifunctionalize a tridimensional macroporous alumina scaffold with a biomimetic calcium phosphate (CaP) coating combined with a silver-based extra-thin film to enhance bioactivity and provide an additional antibacterial effect. The porous alumina scaffolds were fabricated through a powder metallurgy technique, followed by biomimetic deposition and DC magnetron sputtering. The coatings were characterized using SEM/EDS and AFM measurements to examine their morphology and topography. To evaluate the osteoconductive response of the materials, in vitro tests were conducted by immersing the samples in Simulated Body Fluid (SBF). The bioactivity tests revealed that the CaPAgO coating, in line with the roughness surface and free surface energy values, exhibited a higher Ca/P ratio formation. This indicated an increased affinity for apatite adhesion, ultimately leading to a higher osseointegration ability compared to the CaP-Ag coating. Furthermore, the CaP-AgO coating demonstrated superior activity against S. aureus. These findings demonstrate the potential of the multifunctional coatings to address the challenges associated with inert ceramic implants by promoting bioactivity and combating bacterial infections.
引用
收藏
页码：6155 / 6165
页数：11
相关论文
共 61 条
  • [11] Hayashi K., Ishikawa K., Endowing osseointegration ability to bioinert alumina by carbonate apatite coating, Surface. Interfac., 36, (2023)
  • [12] Nobles K.P., Janorkar A.V., Williamson R.S., Surface modifications to enhance osseointegration–Resulting material properties and biological responses, J. Biomed. Mater. Res. B Appl. Biomater., 109, pp. 1909-1923, (2021)
  • [13] Wegst U.G.K., Bai H., Saiz E., Tomsia A.P., Ritchie R.O., Bioinspired structural materials, Nat. Mater., 14, 1, pp. 23-36, (2014)
  • [14] George S.M., Nayak C., Singh I., Balani K., Multifunctional hydroxyapatite composites for orthopedic applications: a review, ACS Biomater. Sci. Eng., 8, pp. 3162-3186, (2022)
  • [15] Hashimoto M., Ogawa T., Kitaoka S., Muto S., Furuya M., Kanetaka H., Abe M., Yamashita H., Control of surface potential and hydroxyapatite formation on TiO2 scales containing nitrogen-related defects, Acta Mater., 155, pp. 379-385, (2018)
  • [16] Gonzalez-Estrada O.A., Pertuz Comas A.D., Ospina R., Characterization of hydroxyapatite coatings produced by pulsed-laser deposition on additive manufacturing Ti6Al4V ELI, Thin Solid Films, 763, (2022)
  • [17] Chernozem R.V., Surmeneva M.A., Krause B., Baumbach T., Ignatov V.P., Tyurin A.I., Loza K., Epple M., Surmenev R.A., Hybrid biocomposites based on titania nanotubes and a hydroxyapatite coating deposited by RF-magnetron sputtering: surface topography, structure, and mechanical properties, Appl. Surf. Sci., 426, pp. 229-237, (2017)
  • [18] Gu Y., Wei L., Zhang Z., Van Dessel J., Driesen R.B., Lambrichts I., Jacobs R., Tian L., Sun Y., Liu Y., Politis C., BMP-2 incorporated biomimetic CaP coating functionalized 3D printed Ti6Al4V scaffold induces ectopic bone formation in a dog model, Mater. Des., 215, (2022)
  • [19] Silva A.D.R., Rigoli W.R., Mello D.C.R., Vasconcellos L.M.R., Pallone E.M.J.A., Lobo A.O., Porous alumina scaffolds chemically modified by calcium phosphate minerals and their application in bone grafts, Int. J. Appl. Ceram. Technol., 16, pp. 562-573, (2019)
  • [20] Guo J., Zhou H., Wang J., Liu W., Cheng M., Peng X., Qin H., Wei J., Jin P., Li J., Zhang X., Nano vanadium dioxide films deposited on biomedical titanium: a novel approach for simultaneously enhanced osteogenic and antibacterial effects, Artif. Cells, Nanomed. Biotechnol., 46, pp. 58-74, (2018)
1234567